Principal Scientist - Computational Chemistry

Cambridge, Massachusetts
January 22 2021
Position Type
Full Time
Organization Type

Seeking a talented individual to join the Computational Chemistry team of Internal Medicine/Discovery Network Chemistry. The candidate is expected to deploy computational techniques to impact project progression and develop or improve computational chemistry methods to achieve such goals. A strong understanding of fundamental physical chemistry theory, knowledge in data modeling, and familiarity with one or more modeling software packages are required.


The position involves the application of a wide variety of computational approaches, including hit identification, lead optimization, structure-based drug design, ligand-based design, pharmacophore modeling, HTS analyses, QSAR and in silico modeling of ADME/Tox, to build hypotheses and influence design small molecule drug candidates. The candidate is expected to develop novel computational approaches and workflows to solve specific problems in drug discovery.

Technical Skill Requirements
  • Knowledge in one or more areas of the computational chemistry discipline, such as molecular dynamics and structure-based design. Knowledge in ligand-based design, quantum mechanics, QSAR, homology modeling and/or pharmacophore modeling is a plus.
  • Demonstrated problem solving abilities in a collaborative team environment is required.
  • Solid knowledge of Linux environment and practical experience in one or more programming environment such as Shells, Python, R, or Jupyter, etc.
  • Experience in at least one modeling software tool/package (i.e. Schrödinger, MOE, etc.) is required
  • Knowledge of a target family of therapeutic interest, such as GPCRs, Kinases or Ion Channels, and/or other areas such as Medicinal Chemistry, Pharmacokinetics & Pharmacodynamics, Drug Safety, Chemical Biology, Computational Biology, and Bioinformatics is required.
  • Background and experience in statistics and deep/machine learning techniques is a plus.

Education and Experience
  • Ph. D. in computational chemistry or relevant discipline and 2-4 years of industrial experience.
  • 2-4 years of industrial experience is required

Other Job Details:
  • Last Date to Apply for Job: February 5, 2021
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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