QC Analyst - Molecular Biology

North Carolina - Morrisville, North Carolina
January 20 2021
Position Type
Full Time
Organization Type

The successful applicant will have significant experience in viral vector quality control related to molecular biology and Next-Gen Sequencing. The position is heavily focused on benchwork and sequence analysis, the applicant should have a desire to continue in a laboratory focused role. This position will join a larger team of scientists across multiple sites focused on advancing Pfizer's gene therapy platform. The scientist will be a key member of the Quality Control (QC) team that will support the production of viral constructs through quality control assays including: qPCR, Next-Gen sequencing, protein analytics (CE-SDS, silver staining, capsid screening), endotoxin testing, and DNA content assessment. The scientist will be responsible for working with fellow colleagues to perform standard QC assays in a reproducible and timely fashion.

  • Pay close attention to experimental details, generate robust and consistent results. Manages time and workload efficiently.
  • Takes the initiative to solve scientific problems and contribute to their resolution. Ability to work in a fast-paced team environment with changing priorities. Works under minimal supervision.
  • Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams.
  • Support laboratory activities by monitoring lab equipment and maintaining a clean and safe working environment.

  • Bachelor's degree with 6 + years of experience or Masters degree with 5 years of experience with a degree in a biological discipline (Molecular Biology, Bioinformatics, Biotechnology, Virology, or equivalent).
  • Demonstrated capabilities in molecular techniques: qPCR, protein analysis, DNA purification/analysis.
  • Experience with aseptic technique, strong quantitative bench skills, experience in quality control assays for viral production, purification and quantification.
  • Able and willing to learn new procedures and techniques.
  • Applicants should be self-motivated, organized, capable of working independently and in a collaborative environment.
  • Ability to prioritize and multi-task concurrent project demands, while maintaining exceptional attention to detail as well as organization.
  • Strong computer skills in Microsoft Office required e.g. MS Word and MS Excel.

  • Experience with QC of viral vectors for gene therapy.
  • Experience with bioinformatic processes to evaluate next-generation sequencing data, sequencing analysis software, and large dataset processing
  • Experience with CE-SDS and cIEF.
  • Experience with ddPCR.
  • Experience with denaturing gels for DNA analysis.
  • Experience with plasmid production and analysis, and experience with VNTI or related program.
  • Experience with plasmid production and analysis, and experience with VNTI or related program.
  • General knowledge of AAV.
  • Able to communicate effectively to all levels of the organization.

Other Job Details:
  • Last Date to Apply for Job: January 25, 2021
  • Eligible for Employee Referral Bonus
  • Relocation support available


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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