Scientist, Synthetic Biology

Cambridge, Massachusetts
January 20 2021
Position Type
Full Time
Organization Type

We are seeking a candidate specializing in molecular or synthetic biology to work in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. In this role the candidate will apply molecular and synthetic biology approaches to genome engineering and protein expression in mammalian cell systems for the production of biotherapeutics. The candidate will work with senior scientists within the group to advance biotherapeutic candidates in the discovery space to support the large molecule discovery portfolio across Pfizer.

  • Provide molecular biology support for development of mammalian cell lines stably expressing recombinant protein biotherapeutics.
  • Provide cell culture support for pilot expression studies.
  • Routinely provide updates at project meetings.
  • Proactively evaluate new technologies and implement new features and functionality into the discovery pipeline.
  • Work with the head of group, project leads, and other senior group members on experimental design and providing data packages with the goal of identifying and advancing best strategies.
  • Successful candidate will be involved in the design and execution of projects with the ability to operate independently.

  • BS/MS degree with 5+ years of experience in the area of synthetic biology/bioengineering .
  • Extensive hands on experience with a wide range of molecular biology techniques, including design and execution of DNA assembly using strategies such as Gibson and InFusion.
  • Experience with gene expression quantification (qPCR, RT-qPCR or ddPCR).
  • Experience in mammalian cell culture, genome engineering and stable cell line generation.
  • Strong communication skills, written and oral and ability to work in team.

  • Prior experience with gene therapy is highly desirable.
  • Demonstrated knowledge of antibody structure and function is preferred.
  • Experience with library design and screening is a plus.

  • Eligible for Employee Referral Bonus: Yes
  • Last Date to Apply: February 9, 2021
  • #LI-PFE

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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