Interested in cardio-oncology? This fast-growing area in cardiovascular medicine studies the effects of cancer therapies on heart and blood vessels. Cancer survivors are far more likely to suffer from cardiovascular disease later in life than people without cancer. Damage to microvessels is a main driver of many radiation exposure-induced health problems, including cognitive decline, stroke, accelerated atherosclerosis and heart failure. Mitochondrial injury plays a prominent role in radiation injury. Since radiation therapy is often combined with newer chemotherapy agents, we are expanding our studies to include effects of combination therapies.
The Grumbach lab has a strong interest in mitochondrial dysfunction in vascular disease. We are looking for a motivated young scientist who is interested in studying the side effects of radiation therapy on mitochondrial Ca2+ handling, mechanisms of transition to chronic injury and initial testing of new nanoparticle-based therapies. We are particularly interested in cognitive decline and vision loss after radiation therapy due to microvessel disease and have imaging techniques and behavioral assays established in the lab. We have strong collaborations with our colleagues in redox/radiation biology, radiation oncology, ophthalmology, neurobiology and pharmacy at the University of Iowa.
We are looking for a candidate who has a background in at least one of the following areas: mitochondrial biology/radiation biology, neuro- or vascular biology. Experience in cell culture, molecular biology and histology/immunohistochemistry is required. Further, previous experience in in vivo imaging, histology/immunohistochemistry, ex vivo vasoreactivity and Ca2+ imaging is desirable. Additional exposure to genetic animal models of cardiovascular disease is also desirable. The successful candidate will have access to in vitro and in vivo research models, as well as advanced radiation and imaging equipment. We will provide ample opportunity to acquire new skills and collaborate with others during the fellowship. We have several related studies on mitochondrial biology, in particular, mitochondrial Calcium handling. A MD with research experience and strong commitment to scientific endeavor will also be considered for the position. The successful candidate should qualify for training grants and postdoctoral fellowships.