Postdoctoral Position in Immunotherapy, Bioinformatics, RNA and Chemical Biology, and Drug Design

Available immediately for highly motivated recent Ph.Ds and/or MDs with strong training in biochemistry, bioinformatics, immunology, molecular and cell biology, virology, medicinal chemistry or chemical biology to participate in the following projects involving multidisciplinary teams of clinicians and basic science investigators: (a) investigate RNA biology mechanisms in immunotherapy; (b) identify epitranscriptomics roles in regulating cancer and host-pathogen interactions by preforming biochemical and genomics studies; (c) develop and employ human stem cell derived lung organoids and cancer stem cell based disease models; (d) structure-based design and synthesis of new drug candidates to treat cancer and viral infections. Technologies employed in our projects include CRISPR, RNAi, single cell genomics (scRNA-seq and scATAC-seq), bioinformatics, proteomics, HT RNA-seq, gene editing, in vitro and vivo models for immunotherapy, computational drug design and synthesis, and biochemical kinetics assays to analyze compound activities. Strong publication record and training to perform independent research are required for further consideration. We highly value and encourage applications from minority groups. For examples of our multidisciplinary work and technologies used in our work, see https://ranalab.ucsd.edu and representative publications: EMBO J. (2020)39:e104514; PNAS, 2020 117 (33) 20159-20170; ACS Chemical Biology 2021,https://doi.org/10.1021/acschembio.0c00841; Cell Reports. 2020 Jan 28;30(4):969-983.e4. doi: 10.1016/j.celrep.2019.11.020.; EMBO J. 2019 Apr 15;38(8); MBio. 2019 Sep 24;10(5); Cancer Research, 2017 Nov 15;77(22):6330-6339; Cell Stem Cell, 2016 Aug 4;19(2):258-65; Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002; Cancer Research, 2016 Oct 1;76(19):5777-5787. Nature Microbiology, 2016, 16011 (2016); J Med Chem, 2016 Aug 25;59(16):7677-82; Nat Rev Drug Discovery 2014, 622-38, Molecular Cell. 2014, 1005-19; PNAS 2014,1002-7; Cell Stem Cell. 2014, 523-34; Cell Reports. 2014, 327-37; Genome Biol. 2013, R149, Nature Communications. 2012, 1085, EMBO J. 2011, 823-34, Molecular Cell, 2009, 696, Nature Biotechnology, 2008, 1187-92, J Med Chem. 2012, 6328. 

Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities. Applicants should send CV and names and addresses of three references to ranaoffice@ucsd.edu: Administrative Coordinator, Rana Laboratory, Division of Genetics, Moores Cancer Center, Institute for Genomic Medicine, and Center for Drug Discovery Innovation, University of California San Diego, La Jolla, California, USA.