Investigator

We are seeking scientists with experience in neuroscience, metabolic, and/or cardiovascular research either in academia or industry. This biologist will join an energetic team in the GSK Novel Human Genetics Research Unit (NHG RU) with the goal of discovering and developing medicines for diseases with a significant unmet medical need. You will be a biologist with experience in the application of a wide range of in vivo models. In this role you will be responsible for identifying new molecular targets and establishing and implementing new in vivo assays for drug discovery projects. This is an exciting bench-based role in a dynamic matrix team environment that will allow the successful candidate to have a critical contribution in our drug discovery efforts.

The Novel Human Genetics Research Unit (NHG RU) was formed in 2019 to identify and advance novel targets with high genetic association to disease. This is based on the observation that targets with high human genetic evidence supporting their causal role in a disease state improves success in drug discovery by two-fold. The NHG RU is therapeutically broad and complements other research units within GSK which have strategic focuses on immunology and oncology. The current portfolio includes projects focused on neurological diseases including Parkinson's, Alzheimer's, ALS, FTD, migraine and pain, in addition to cardiovascular and metabolic diseases including heart failure and liver disease. The remit of NHG RU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform Phase 1 first-time in human and proof of mechanism studies in the clinic. This goal is enabled through strategic external (23andMe, UK Biobank, FinnGenn, Laboratory of Genomic Research, Public-Private Consortia) and GSK-internal partnerships (Functional Genomics, AI/ML, and Medicinal Science and Technologies).

The successful candidate will have knowledge, understanding and experience in state of the art neuroscience, metabolic, and/or cardiovascular in vivo models. Only a talented individual, who aspires to learn and work collaboratively in teams will succeed in this role. Though drug discovery experience is highly desirable, this is not essential. The successful candidate will be one who is science driven, innovative, understands project needs and establishes relevant biological assays, effectively trouble shoots challenges, assumes personal accountability, and is courageous. The candidate must be keen to learn through experience, in order to advance in their career.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Hands-on execution of laboratory experiments, data recording/analysis, and strict adherence to data integrity principles.
• Able to establish, design, perform, and validate in vivo assays.
• Assimilate and evaluate in-house and publicly available data in support of new target identification and evaluation as well as supporting ongoing projects
• Provide scientific insights based on knowledge and experience and deliver robust results to drug discovery matrix teams to enable decision making.
• Effectively resolve scientific and technical challenges using knowledge and subject matter expertise/experience to enable program progression.
• Maintain knowledge of relevant literature, and effectively incorporate knowledge and technology to positively impact projects.
• Clear communication of study results and impact at internal and external meetings.
• Contribute to triage of new targets identified through genetic analysis from our alliance with 23andMe as well as other public-private consortia

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Advanced degree (MSc, PhD or MD/PhD) with 2 years of physiology/pharmacology research experience in neuroscience, metabolic, or cardiovascular disease
• Demonstrated experience in establishing robust in vivo assays

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience in neurodegeneration and/or pain research including proficiency in neuropharmacology projects focusing on Alzheimer's, Parkinson's, ALS and pain.
• Experience in liver disease models including NASH and ALD
• Proficiency in models of cardiovascular disease including techniques to measure hemodynamics and cardiac function.
• Prior experience in drug discovery either at pharma or in biotech.
• Knowledge of in vitro cell model systems (cell lines, primary cells, iPSCs) and techniques (molecular biology, cell biology and biochemistry)
• Demonstrated experience in working independently as well as collaboratively in a matrix environment across multi-disciplinary teams to support multiple projects.
• Outstanding writing and oral communication skills with the ability to present results in an organized and concise manner.
• Demonstration of scientific integrity and rigor in prior work.
• Strong analytical and problem-solving skills.
• Comfortable working in a cross-functional team environment.
• Ability to prioritize, manage time efficiently, and implement creative solutions to meet program needs.
• Commitment to continual improvement by reading and applying the latest scientific literature, methodologies and technologies.
• A high level of integrity and desire to develop transformational medicines that bring benefit to patients
• Intellectually mature, resourceful and technically diverse, adept, versatile, and resilient.
• Ability to adapt to changing priorities.

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk, governance and control, managing ambiguity and paradox.
• Managing individual performance.
• Creating a performance culture and driving results, prioritisation, execution, delivering performance.
• Setting strategic direction and leading on-going organisational transformation.
• Building a resilient organisation.
• Building strong relationships and collaboration in service of common goals, engaging the organisation and building trusted external networks for mutual benefit.
• Managing P&L and capital allocation.

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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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