Bioimmunologist

GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs.

GSK's Adaptive Immunity Research Unit (AIRU) identifies and develops novel therapeutic targets for patients with unmet medical need, through leveraging genetic, experimental and genomic approaches fromgenetic collaborations (23andMe, UK Biobank, Finngen), building drug hypotheses from output of functional CRISPR editing screens, driving targets through milestone governance decisions, or much more…The Genomic Immunologygroup, as part of AIRU, strives to explore that rich data landscape to derive crucial insight, and to integrate directly with our groundbreaking experimental science. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer.

Description:

The Genomic Immunology research team in Cambridge, MA is seeking a self-motivated, energetic and creative immunologist with a critical and innovative thinking to take part in the development of novel therapeutics for the treatment immune disorders with high unmet medical need. This individual will work independently and/or in partnership with cross-functional project dynamic teams in a multidisciplinary matrixed environment to investigate the biology of novel targets using functional molecular genomic tools, to evaluate the effects of newly developed drug lead candidates on immune cell functions and to make significant and high-impact contributions in multiple GSK drug discovery programs.

Responsibilities:

• Perform hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation.
  
• Design and conduct human and rodent cell- and tissue-based immunoassays for target identification and validation.
  
• Generate, analyze, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward
  
• Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy.
  
• Share in responsibilities to support general lab functions
  

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Immunology, Cell Biology or related fields with a track record of publications
  
• Postdoctoral training with 1+ years experience working independently to design, conduct, and analyze experiments as well as in (electronic) lab notebooking.
  
• 1+ years hands-on experience utilizing functional genomics approaches (CRISPR-Cas, si/hRNA) as well as multicolor Flow-cytometry analysis for phenotypic screening and target ID/validation in cell lines or primary immune cells.
  

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Cell culture: Isolation and sterile tissue culture of mammalian cell lines and immune cell subsets
  
• Cell-based assay development using primary rodent and human immune cells and immortalized cell lines
  
• Molecular biology (included but not limited to Next Generation Sequencing, Microarray, CRISPR gene editing, qPCR, NanoString, scRNA-Seq)
  
• Multicolor Flow-cytometry analysis (set-up, acquisition, analysis and reporting)
  
• Protein detection (included but not limited to ELISA, Luminex, MSD, Western blotting)
  
• Pre-clinical animal models of autoimmune disorders
  
• Previous drug discovery experience in a biopharmaceutical setting
  
• Outstanding written and oral communication skills as well as excellent interpersonal skills
  
• Learning agility and drive to continuously improve and develop
  
  

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  
• Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  
• Continuously looking for opportunities to learn, build skills and share learning.
  
• Sustaining energy and well-being
  
• Building strong relationships and collaboration, honest and open conversations.
  
• Budgeting and cost-consciousness
  

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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