Research Scientist Cell Therapy/Immuno Oncology

La Jolla, California
Compensation commensurate with experience. Comprehensive benefits effective on start date.
December 18 2020
Job ID 823
Position Type
Full Time
Organization Type

Position Title:  Research Scientist in Cell Therapy/Immuno-Oncology                                
Who We Are:
Calibr at Scripps Research is a division of Scripps Research focused on innovative research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.​  Calibr’s mission is to translate innovate ideas from bench to beside in collaboration with academic and pharma partners.  This is enabled by Calibr’s unique position between academia and pharma, allowing for a bridge to catalyze new science that can be transformative in the lives of patients.  Calibr’s lead programs include a T cell engager immunotherapy, CCW702 currently in a Phase I trial for prostate cancer and a novel “switchable” CAR-T cell therapy in a Phase I trial for patients with hematological malignancies. We are recruiting talented scientists who have a passion for making a difference in the lives of patients.

The Position:
Calibr is seeking a talented Research Scientist in the area of Immuno-Oncology. This position will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into first in human clinical trials. Specifically, projects will be focused on the development of a cell gene therapy referred to as chimeric antigen receptor T (CAR-T cell) and in the development of immunotherapies known as CD3 T cell recruiting bispecific antibodies.  Both platform technologies have the potential to have curative responses in the clinic for cancer patients.  While working within the scope of these projects, this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others.  Calibr’s open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups.  Publication in high impact journals and conference/meeting attendance will be highly encouraged as part of this position.  This position will receive hands on training in translational research and is expected to bring the basic scientific proficiencies listed below at the start.  This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr team.

Essential Duties and Responsibilities:

  • Cell biology including working with primary human immune cells and culturing multiple cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
  • Design and execution of project plans involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
  • Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
  • Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, Western blots, etc will be within the scope of work.
  • Preparation of reports and presentation of results at regular team meetings.

Qualifications and Experience:

  • BS,BA, MS or MA with 5 years' experience in industry, or PhD in biology, chemical biology, biochemistry, or related area required.
  • Impeccable attention to detail, and excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation.
  • Highly motivated, creative, and devoted to project goals.
  • Able to collaborate proficiently and communicate effectively with colleagues and management teams.
  • A strong background in cell culture is essential.
  • Hands-on experience with in vitro assays commonly used in immuno-oncology is essential.
  • Experience with multi-color flow cytometry and flow data analysis is required.
  • Experience and knowledge of the immune system is a required. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
  • Hands on experience in cellular immunotherapies is preferred.
  • Experience preparing reagents for in vivo assays and In vivo experience preferred but not required.
  • Experience with cell transfection and transduction systems is preferred.
  • Experience with molecular biology techniques is preferred.
  • Experience using Prism, FlowJo, and Office software is important.
  • Highly motivated, creative, and devoted to project goals.
  • Able to collaborate proficiently and communicate effectively with colleagues and management teams.
  • Able to contribute in a meaningful way to scientific discourse.

*Visa sponsorship is not available for this position.

Physical Requirements:
This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.


Commensurate with experience

EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Please apply on our website careers page: 

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