Postdoctoral Position

Location
Baltimore, Maryland (US)
Salary
Salary is competitive and commensurate with experience + healthcare benefits.
Posted
December 14 2020
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

A 3-year post-doctoral position in a laboratory research program on targeted alpha-particle emitter therapy of cancer is available in the Department of Radiology at The Johns Hopkins University, School of Medicine. Candidates with an interest in translational research and a background in radiochemistry/organic or inorganic chemistry, radiobiology/molecular biology/biochemistry, and/or radionuclide physics/dosimetry are encouraged to apply. The project involves the development and application of in vitro and in vivo models for investigating and optimizing novel strategies for the clinical implementation of targeted alpha-particle emitter therapy of cancer. The work will be performed in close collaboration with the Radiation Oncology Department and will involve the collection of tumor and normal organ dose-response data on a small animal irradiator (SARRP) with corresponding dose-response data from radiopharmaceutical therapy (RPT) using targeted alpha-emitters (αRPT). The objective of the work is to rigorously define RBE values for normal tissue and selected tumor types. Although this would be the primary focus of the candidate, the Sgouros lab provides a wide-range of research activities, including the use of checkpoint inhibitors to activate the immune system in combination with αRPT, microscale imaging studies using an alpha camera, patient-specific dosimetry studies using Monte Carlo methods, cell and molecular biology methods to delineate DNA repair pathways, pharmacokinetics and pre-clinical dosimetry studies of novel radiolabeled therapeutic agents, alpha—emitter labeled therapy of canine osteosarcoma in collaboration with a veterinary group in Radiology. Johns Hopkins University, School of Medicine and affiliated institutions include a nanobiotechnology institute, an NCI-designated cancer center, advanced pre-clinical and clinical imaging facilities and an academic environment that fosters interdisciplinary research. The Sgouros Lab also has ongoing collaborations with faculty in the Whiting School of Engineering. Candidates with experience using radiolabeled agents, performing clonogenic assays, in vitro and have hands-on experience performing pre-clinical animal studies are best aligned for this position. Apply by sending your CV to George Sgouros, at gsgouros@jhmi.edu.