Senior Scientist, Chemical Biology

ROLE SUMMARY
Pfizer is seeking applications for a Senior Scientist with extensive mass spectrometry-based proteomics experience. Such a candidate will be a highly motivated and creative scientist with the desire to lead and implement innovative proteomic capabilities across our east coast portfolio pipeline (includes Inflammation and Immunology, Rare Disease and Internal Medicine). This person will work in the Chemical Biology group enabling impact across the small molecule east coast portfolio from early exploratory target identification through the drug discovery pipeline and into early clinical development.

As a Senior Scientist in the Chemical Biology group your work will drive a deeper understanding of the mechanism of action of our molecules and cellular targets. Relevant methodologies include, but are not limited to identification of novel targets, small molecule target deconvolution, small molecule target occupancy studies using chemical probes, protein turnover studies and small molecule-protein interactome analyses.

ROLE RESPONSIBILITIES
• Develop innovative chemical biology tools, with an emphasis on quantitative protein mass spectrometry technologies, across multiple disease areas to advance portfolio projects.
• Enable new small molecule projects in the portfolio, through collaborations with disease area biologists and chemists.
• Present and report data with follow up discussions for project teams including data impact and interpretation.
• Enhance the external reputation of Pfizer's Chemical Biology capabilities through publications and presentations at leading conferences
• Drive innovation in all aspects of laboratory operations including sample preparation, running samples on the spectrometers, data analysis and interpretation.
• Work with local leadership to put in place an active program of self-development in chemical biology skills

BASIC QUALIFICATIONS
• Doctorate level degree in proteomics/biochemistry/cell biology or related field with post- doctoral experience in chemical biology/chemo-proteomics.
• Applied mass spectrometry-based proteomics required.
• Experience and knowledge in the operation and maintenance of different types of mass spectrometers including Q Exactive Hybrid Quadrupole and Orbitrap Fusion Lumos Tribrid
• Experience with quantitative proteomics data analysis, including Proteome Discoverer, MaxQuant, or equivalent analysis platforms is required. Some programming expertise is a plus.
• A strong desire to increase knowledge of the key proteomics and multi-omics methodologies and tools emerging in pharmaceutical drug discovery
• Excellent verbal and written communication skills.
• Examples of peer-reviewed publications from scientific work to date
• Experience of working in teams of scientists to deliver objectives

PREFERRED QUALIFICATIONS

• Proficiency in protein biochemistry techniques (examples may include subcellular fractionation, western blot, in-gel fluorescence) is preferred.

• Expertise in biorthogonal chemistry, site-selective protein modification, photo affinity cross-linking, activity based protein profiling (ABPP) is a plus.

• Industry experience is preferred.

#LI-PFE

Other Job Details:

• Eligible for Employee Referral Bonus

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development