Postdoctoral Position in 3D Genome Architecture and DNA Replication Timing
The Rivera-Mulia Lab is seeking a post-doctoral researcher to work in the area of genome architecture and DNA replication timing. The research project is focussed in the identification of regulatory elements of 3D genome architecture and the temporal order of DNA replication, as well as to determine how 3D genome organization is remodeled during development and evolution. This project is fully funded by a recently awarded NIH grant (R35GM137950) but candidates are encouraged to apply for eligible fellowships. The successful candidate will identify regulatory elements and track their activation during development using highly synchronous human embryonic stem cells differentiation systems. Distinct genomic methods will be exploited to map DNA replication timing, 3D genome organization and gene expression (Repli-seq, Hi-C, Hi-ChIP, RNA-seq) and genome editing technologies (CRISPR/Cas9) will be used for removal/insertion of cis-regulatory element candidates. A Ph.D. in biochemistry, molecular and cellular biology, developmental or related areas is required. Candidates with strong expertise in genomics and stem cell biology will be considered. Preference will be given to candidates with skills in chromosome conformation capture methods (Hi-C) and/or genome editing technologies. Bioinformatic skills are an asset but not required as data analysis can be managed collaboratively. Salary will be commensurate with NIH guidelines (NOT-OD-20-070).
Research in the Rivera-Mulia Lab (https://sites.google.com/umn.edu/rivera-mulialab) focuses on understanding how DNA replication timing and the spatial genome organization are regulated during development and how nuclear architecture alterations disrupt gene function in disease. To address these questions, we exploit genome-wide characterization of nuclear architecture, replication timing and gene expression to construct integrative models of nuclear function.
The department of Biochemistry, Molecular Biology and Biophysics (https://med.umn.edu/bmbb) has 53 faculty members with highly diverse research programs and provides opportunities for postdoctoral career development that include training grants to support the transition to independent investigator status.
The intellectual environment at University of Minnesota Medical School is highly motivating, it includes more than 3,000 faculty members and is ranked among the top 30 institutions in NIH-sponsored research. The University houses the first stem cell research institute in United States (Stem Cell Institute), a NIC-designated center for cancer research (Masonic Cancer Center) and the Developmental Biology Center (DBC). The University also has excellent core facilities including the Genome Engineering Shared Resource with CRISPR/Cas9-mediated genome editing services, the Genomics Center (UMGC) with state-of-the-art genomic technologies for Next-generation Sequencing (NGS), the Minnesota Supercomputing Institute (MSI) with resources for high performance computing, the Flow Cytometry Resource and the Imaging Center.
University of Minnesota Twin Cities campus is also located around the scenic Mississippi River, within walking distance to Minneapolis downtown that offers many entertainment and culture opportunities.
The University is committed to promote a diversity of views, experiences, and ideas in the pursuit of research, scholarship, and creative excellence. Hence, candidates from underrepresented backgrounds are encouraged to apply.
Prospective candidates should send Dr. Rivera-Mulia (email@example.com) a cover letter describing your interest in nuclear organization research, career interests and your suitability for the position, their CV with a complete list of your publications and a letter of recommendation from your most recent advisor.
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