Principal Scientist

La Jolla, California
November 24 2020
Position Type
Full Time
Organization Type
"Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact."


Pfizer's Cancer Vaccines and Immunotherapeutics department is developing state-of-the-art immunotherapy regimens that will benefit cancer patients. This Principal Scientist position will join a highly skilled and dedicated team to apply expertise to advancing from preclinical research through early clinical development.

Specific responsibilities include:
  • Serving as a Research Leader on one or more CD3 bispecific antibody programs
  • Apply scientific expertise in tumor immunology, antibody drug development, and relevant experimental and technical areas to advance programs, including designing and performing experiments to assess target validity, lead antibody performance, drug mechanism of action, disease selection, biomarker identification, etc. This includes molecular, cellular (in vitro), and in vivo approaches
  • Work effectively with cross-functional teams, providing specialized knowledge and influence to maximize program speed and success
  • Contribute expertise in tumor immunology to other Cancer Vaccines and Immunotherapeutics programs to aid development and advancement of the portfolio
  • Provide ideas and perform research to identify new opportunities to develop immune-mediated therapeutics
  • Directly manage a team of 1-3 experimental scientists, maximizing employee productivity, engagement, and professional development
  • Strengthen department's overall immune-oncology capabilities and expertise, for example by expanding immunophenotyping assays and implementing new methods and technologies
  • Contribute to preparation of drug development and regulatory documents (e.g., IND submissions), being responsible for preclinical biology components
  • Effectively communicate strategy, methodology, progress, and challenges to multiple stakeholders and partners, including senior executives and governance committees
  • Represent Pfizer at external conferences and scientific events and publish results in high quality scientific journals
  • Lead or participate in collaboration with external academic and industry partners to advance programs and develop new ones.

  • Ph.D. in oncology, immunology, or other related fields
  • At least 5 years of post-Ph.D. experience in the area of antibody drug discovery and development for the treatment of cancer
  • Demonstrated productivity working as part of cross-functional team

  • Expertise in T cell biology and tumor immunology, including various murine models of cancer
  • Experience in therapeutic antibody drug development
  • A strong record of achievement, including advancement of cancer drug projects and/or publications in leading journals.
  • Outstanding communication and ability to both influence and motivate others.

  • Required to work with BSL2 infectious viruses (e.g., Vaccinia and adenovirus) and must receive and maintain required vaccinations or provide satisfactory proof of same.

•Relocation eligible
•Eligible for employee referral bonus

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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