Senior Scientist

South San Francisco, California
November 24 2020
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

Centers for Therapeutic Innovation (CTI) is an entrepreneurial network of partnerships with leading academic medical centers (AMC) that aligns leading scientific and clinical experts from the AMCs with Pfizer's world-class scientists, drug development capabilities and breadth of resources to speed the translation of breakthrough science into innovative medicines for patients.

Pfizer scientists will work alongside academic investigators towards the common goal of translating science into novel Proof-of-Mechanism (PoM) studies across multiple therapeutic areas and indications to increase the probability of reaching Proof-of-Concept (PoC) and ultimately bring novel and differentiated medicines to patients.


The candidate will be an essential member of the CTI-West Biology Group. He/she will use their assay development expertise to design and execute experiments to address aspects of basic and translational biology of drug targets, molecular pathways, and relevance to human disease. The candidate will assist with the evaluation, characterization and validation of the mechanism of action of antibody, protein and/or small molecule drug candidates. A variety of cellular, biochemical and pharmacological methods will be employed using human cell lines and primary cells to effectively translate innovative ideas into drugs.

The individual will participate in strategic discussions, supports other scientists in executing the plan, coordinates program activities, and aligns stake holders, both internal and external, to meet timelines and advance the program through the pipeline. The ideal applicant will have extensive experience in basic research, assay development, drug screening and a desire to continue in a laboratory-focused role. The successful candidate will have a proven track record of scientific productivity as evidenced by publication in journals and ability to participate in a highly matrixed and innovative research environment.

The applicant will function as a member of multidisciplinary project teams. He/she will present results and recommendations at local project team and related meetings as well as potentially lead these proceedings and/or teams. The candidate will collaborate closely with other members of CTI-California, CTI and Pfizer scientists at other sites, and our academic partners to ensure meeting aggressive project deliverables. The candidate is expected to embrace and embody the entrepreneurial spirit and biotech-like culture, values and goals of the CTI and contribute to creating an exciting, collaborative, productive and scientifically rigorous working environment.


Provide the primary groups or key positions that this position will have interaction with as a regular part of the position responsibilities. Include any external interactions as appropriate.

The qualified candidate will be part of a multidisciplinary teams and will collaborate very closely with other members of the CTI and Pfizer. Additonally, the candidate will work closely with our academic partners and members of the affiliated local scientific community.

The candidate would report to the Sr. Prinicpal Scientist of Biology at CTI-CA and hold dotted line reporting accountability to respective CTI project team leaders.

  • Minimum PhD (+3 yrs) /MS (+5 yrs) in Cancer Biology, Cell Biology, Immunology, Molecular Biology, Biochemistry, or related field
  • Experience conducting laboratory research in an academic or pharmaceutical setting
  • Strong background in cell biology, cell based assay development, and/or molecular pathways analysis
  • Previous experience in drug development in pharma and/or biotech environment is preferred
  • Excellent communication skills, both written and oral, and highly organized in terms of goal setting and achieving.
  • Ability to succeed in a small, interactive, non-traditional drug-discovery environment

  • Immunology or immuno-oncology background preferred
  • Expertise and hands-on experience in assay development methods including cellular and biochemical assay development and execution
  • Immunophenotyping and multiparameter flow cytometry experience is required
  • Experience with primary human cells and cell lines is required
  • Ability to design, execute and interpret results in a primarily autonomous manner


Other Job Details:
  • Eligible for Employee Referral Bonus

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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