GSK

Director & Group Leader, Protein Mass Spectrometry

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
October 16 2020
Ref
268082
Discipline
Other, Other
Organization Type
Pharma
Are you energized by an opportunity to lead a group of 9 experienced protein mass spectrometry scientists to drive technical innovations and its project applications to measure biotherapeutics and biomarkers? If so, this Bioanalysis and Biomarkers, Director and Group Leader of Protein Mass Spectrometry role is a great fit for you to explore!

We are looking for a highly motivated, agile protein mass spectrometry technical and project application expert to lead a team in the US Bioanalysis and Biomarkers group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Upper Providence, PA. This exciting opportunity will oversee a group of scientists responsible for using cutting-edge mass spectrometry platforms including hybrid LBA/LCMS techniques to develop and validate novel/bespoke assays for protein biomarker and biotherapeutic endpoints supporting projects from early discovery through the clinic. Data from this group is a key component to understanding the mechanisms of action and pharmacology of large and small molecules in the GSK pipeline. The group has seen a large capital and headcount investment in recent years. Utilizing these novel instrument platforms this group delivers data to support investigations into target engagement biomarkers, pharmacokinetic studies, PK/PD relationships, Critical Quality Attributes (both intact and sub-unit peptide mapping), and target protein turnover.

This Director-level role will provide you the chance to lead key activities to progress your career. These responsibilities include the following:
  • Provide senior scientific leadership and set strategic direction of protein mass spectrometry assays and platforms in BIB. Drive scientific innovations and project applications internally and through academic/vendor/industry collaborations.
  • Champion the collaborations with translational and clinical biomarker leads to design and execute protein mass spectrometry assays to inform patient stratification, target engagement, proof of pharmacology in preclinical and clinical efficacy and safety studies.
  • Drive an assay technology agnostic attitude when providing bioanalytical support to biotherapeutics and seek new areas that protein mass spectrometry may offer additional values to project applications in any modalities.
  • Hold yourself and your group accountable for delivering high quality bioanalytical results and be fully compliant with regulatory requirements.
  • Actively contributes to the development and implementation of worldwide departmental analytical strategy (scientific, quality, regulatory, and contracting).
  • Manage capacity and demands, and work closely with other BIB group leaders to effectively share bioanalytical resource to deliver timely high-quality data to projects.
  • Build effective relationships with the analytically supported groups throughout R&D to balance stakeholder expectations with scientific quality and validation requirements ensuring limitations of assays and data are well understood.


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • PhD in Biochemistry, Biology or Analytical Science
  • 10 years or more of pharmaceutical experience
  • Demonstrated experience with technical leadership on protein mass spectrometry (LC-MS) and universal bioanalytical applications including sample extractions and automations.
  • Experience working in a regulated environment and deep knowledge of international regulatory guidelines
  • Experience translating a project team's data delivery needs into an appropriate assay and act as an analytical scientific expert in discussions on science/project progression within GSK
  • Resource planning and project interfacing experience
  • Experience leading and mentoring a team including skill development, training, and talent development


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • E xperience and knowledge to represent the department in regulatory interactions (questions, and filings) and at high level relevant regulatory meetings (eg FDA, EMA, MHRA).
  • Ability to provide a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor and operational excellence


Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Managing individual and team performance.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Implementing change initiatives and leading change.
  • Sustaining energy and well-being, building resilience in teams.
  • Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
  • Developing people and building a talent pipeline.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Budgeting and forecasting, commercial and financial acumen.


*LI-GSK

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