GSK

GSK Investigator, LGR Functional Genomics

Employer
GSK
Location
San Francisco, CA
Salary
Competitive
Posted
November 03 2020
Ref
269868
Discipline
Life Sciences, Genomics
Organization Type
Pharma
“Technology is key to our innovation strategy at GSK, and CRISPR is one of the most important technologies of our time.” Dr. Hal Barron - Chief Scientific Officer and President GSK R&D

Are you a curious, collaborative and driven scientist looking to help deliver cutting-edge science? The Laboratory for Genomic Research (LGR) is a new functional genomics center on the UCSF Mission Bay campus in San Francisco, CA, representing a novel hybrid model that brings together researchers from UC Berkeley, UC San Francisco, and GlaxoSmithKline under a single roof working on projects both together and independently. The new laboratory will house up to 40 scientists; 12 of whom will be GSK employees working in close partnership with UC employees to develop and apply CRISPR-Cas based functional genomics technologies to collaborative research projects. The outputs of those research projects will be focused on technologies, new drug targets and biological mechanisms that will foster both academic and industrial advances.

As a GSK team member, you will be responsible for supporting collaborative and GSK-only projects for GSK. Working in this multi-faceted, dynamic, and innovative academic-hybrid scientific environment, this role will give you the opportunity to:
  • deploy CRISPR-Cas based approaches to target discovery and validation
  • apply enabling technologies including scRNA-seq, high content imaging, and robotic-enabled pooled and arrayed screening
  • model disease in 2D and with complex 3D cellular systems
  • develop and apply cutting-edge functional genomics tools and relevant enabling technologies


Exceptional scientists with expertise in genetic screening, imaging and/or advanced cell culturing models such as iPSC-derived cell types, organoids, or multi-culture cell models are highly encouraged to apply.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Master's degree with 10 years of experience or Doctoral degree in the natural sciences or other relevant degree (biology or chemistry preferred)
  • Expertise in any of the following (a combination of skillsets preferred):
    • functional genomics screening (CRISPR/Cas9 a plus) in mammalian systems
    • next-generation sequencing (single cell sequencing a plus)
    • complex cellular models including primary cell types, iPSCs, 3D spheroids/organoids
    • advanced imaging techniques including confocal microscope, flow cytometry
    • computational biology and data analytics
    • laboratory automation


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • experience with genome editing or functional genomics screening
  • background in oncology or immunology, ideal
  • expertise in advanced cellular models including primary cell types, iPSCs, 3D spheroids/organoids
  • fluency across a multitude of scientific techniques including genetic, proteomic, imaging, and/or other 'omics technologies
  • fluency with high content imaging
  • project leadership experience
  • proactively identifies and resolves issues and hurdles
  • comfortable defining new ways of working in an ambiguous environment
  • strong track record of delivery


Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk
  • Managing individual and team performance.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Implementing change initiatives and leading change.
  • Sustaining energy and well-being, building resilience in teams.
  • Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
  • Developing people and building a talent pipeline.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Budgeting and forecasting, commercial and financial acumen.


GSKGenetics

*LI-GSK

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