Pfizer

Senior Scientist, BioMedicine Design - Pharmacokinetics, Dynamics & Metabolism

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
November 18 2020
Ref
4794383
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
ROLE SUMMARY

Responsible for the oversight of a few different projects within Research Units and provide BioMedicine Design - Pharmacokinetics, Dynamics & Metabolism (BMD-PDM) - focused guidance and strategic direction to assigned projects from early discovery through loss of exclusivity.

ROLE RESPONSIBILITIES
  • Identifies key BMD-PDM related project attrition risks and in collaboration with internal BMD stakeholders creates and integrates this risk-mitigation strategy into the overarching project strategy.
  • Works with the project team and key personnel in BMD-PDM to implement risk mitigation strategies and the regulatory documentation required in PDM to progress programmes out to a key go/no go decision point in discovery and development.
  • Ensures execution of the BMD-PDM strategy in partnership with BMD scientists. For example, works with bioanalytical scientists to ensure the development of appropriate assays, interfaces with biomarker scientists, PK/PD modelers and other biotherapeutic BMD-PDM partners to develop quantitative translational pharmacology plans, ensure appropriate PK predictions and dose projection approaches, and develop immunogenicity risk assessment and mitigation strategies.
  • As the BMD-PDM lead to project team(s), the scientist is expected to integrate nonclinical pharmacokinetic, pharmacodynamic and metabolism knowledge, influence the preclinical project plans, and in collaboration with BMD protein engineers, drive optimization of biotherapeutic molecules.
  • The candidate will also work with others to advance the science and strategies for prosecuting biotherapeutic projects as well as influence external scientific and regulatory practices through publication and other interactions.
  • Liaises with: Core discipline groups within BMD, and interacts with the Project Leader and scientists in Biology departments, Drug Safety, Pharmaceutical Sciences, and Clinical departments at all stages of discovery and development.


BASIC QUALIFICATIONS
  • PhD with >1 years of work experience in pharmaceutical industry or at least 1 year post-doctoral studies in Pharmacokinetics, PK/PD, or relevant field (or MS/BS with 5 or more years)
  • Understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental)
  • Working knowledge in the pharmacokinetics and disposition of biotherapeutic modalities.
  • Understanding of immunological and other biotherapeutic bioanalytical assays.
  • General understanding of PK/PD modeling and the application to advance projects from idea to clinical development.
  • General understanding of integrating data from multiple sources into a rational understanding of absorption, distribution, clearance, PK/PD, and immunogenicity
  • Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.
  • Excellent oral, written, and presentation skills. Demonstrated through internal and external presentations.
  • Excellent interpersonal relationship skills.


ORGANIZATIONAL RELATIONSHIPS

Core discipline groups within BMD, Project Leader, scientists in Biology departments, Drug Safety, Pharmaceutical Sciences, and Clinical departments

Ability to perform and communicate mathematical calculations

Due to the global nature of some projects supported, occasional flexibility in timing of work hours .

Other Job Details:
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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