Principal Scientist, Biotherapeutic Design - Protein Engineering

La Jolla, California
November 16 2020
Position Type
Full Time
Organization Type

Pfizer's Biotherapeutic Discovery group in La Jolla is seeking an outstanding, highly motivated and proven protein engineering expert. The candidate will be responsible for developing biologics. The primary responsibility will be the engineering of next generation biologics and hit identification/lead optimization of antibodies. Additionally, the candidate will be responsible for working closely with individuals in both protein engineering and biology groups to innovate and develop the next generation of protein therapeutics. The candidate will have access to state of the art protein and antibody engineering technologies and will be expected to continue our tradition of developing world class methods and technologies that enhance our therapeutic discovery efforts.

Job Description:
  • Biologics discovery at the interface between discovery biology and biotherapeutics.
  • Desire to understand underlying biology and mechanism of targets and biologics.
  • Translating their knowledge of protein structure/function into therapeutic molecules.
  • Carry out hands-on lab work to apply protein engineering principles to the generation of novel protein therapeutics.
  • Isolating and optimizing antibodies using Pfizer's proprietary synthetic antibody libraries.
  • Generation of diverse next generation of biologics.
  • Provide strategic direction and innovative approaches across multiple modalities.
  • Work in multidisciplinary and cross-functional teams to develop next generation therapeutics and influence project teams in their decision making and advance biologics through different stages of the development.
  • Independently design experiments, analyze data and troubleshoot methods.
  • Present experimental design and results at internal meetings.

  • Ph.D. in Biological Science (Molecular Biology, Structural Biology, Protein Biochemistry, Cell Biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering) is required.
  • At least 6 years of post-graduate experience in either an academic or industrial setting.
  • An innovator with proven track record in molecular design of biologics, of creative and proactive approach to problem solving, and strong analytical skills
  • Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.
  • Strong motivation, passion and commitment to science and engineering of novel entitie.s
  • A highly-collaborative scientist with broad interests and a diverse background. An ability to work across disciplines and understand the specific needs of collaborators.
  • Strategic thinking with an ability to understand program and therapeutic area needs and translate that understanding into an actionable approach.
  • Outstanding interpersonal, collaborative and oral communication skills.
  • Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques.
  • Ability to analyze and interpret work published in the field and apply it appropriately.
  • Technical expertise should include protein expression and purification, molecular biology, understanding structure-function relationships.
  • Track record of demonstrating analytical skills, creativity and unique problem solving.
  • Strong time management skills and ability to manage multiple projects in parallel.
  • Strong communication skills and ability to present research in a team setting.

  • Previous experience with protein expression and purification methods.
  • Previous experience with antibody engineering.
  • Previous experience with high throughput screening methods.
  • Strong desire and initiative to understand the underlying biology and help propose new ideas and techniques to discover next-generation of protein-based therapeutics with unique functionalities.


Other Job Details:
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus

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