Scientist, Bioanalytical and In Vitro ADME, DMPK

Boulder, Colorado
November 16 2020
Position Type
Full Time
Organization Type
Pfizer Boulder Research is currently seeking a highly motivated and team-oriented candidate for a Scientist position contributing to ADME (absorption, disposition, metabolism and excretion) sciences , facilitating the identification and development of small molecule cancer therapeutics. Specifically, the position is for a bioanalytical role for LC-MS/MS method development within the ADME group. The scientist also will conduct in vitro enzyme kinetic or mechanistic studies, drug metabolism and protein binding studies. Additional responsibilities include authoring of research reports in support of regulatory submissions , and external publications . T he individual will have the unique opportunity to work with project representatives and influence the selection of candidate molecules for drug development.

Job Responsibilities

  • Serve as a bioanalytical LC-MS/MS subject matter expert for the ADME team.
  • Develop novel, rapid and robust LC-MS/MS methods and perform bioanalysis for in vitro biological samples.
  • Oversee innovative high-throughput LC-MS/MS workstations, enhance robustness and bioanalytical capabilities of ADME screens.
  • Conduct in vitro ADME experiments and generate high quality data in a timely manner, review and upload data into databases, write reports, and data QC.
  • Maintain close collaborations with other scientists in the ADME group to enable drug discovery or development portfolio support, trouble-shooting, and technology improvement or development.
  • Provide guidance on chemical modifications that may improve ADME properties.
  • Prepare documents to support regulatory IND filings.
  • Evaluate new technology and methodology that advances our understanding of ADME/PK, target-engagement, etc.

Basic Qualifications

  • BS/MS degree in chemistry, biochemistry, biology, biomedical, pharmaceutical sciences or related field.
  • 5-10 years of bioanalytical experience in the pharmaceutical industry.
  • Hands-on experience and strong trouble shooting skills for LC-MS/MS bioanalysis and method development.
  • Knowledge of ADME/DMPK.
  • Excellent oral and written communication skills.
  • Excellent interpersonal skills and ability to work in a team environment.

Other Job Details:
  • Last Date to Apply for Job: November 20, 2020
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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