Senior Scientist, Tumor Biology-Translational Sciences

La Jolla, California
November 16 2020
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Role Summary

We seek an accomplished Senior Scientist level oncologist to join the Translational Sciences group within Oncology Research & Development (ORD), La Jolla, California. The successful candidate will join a dynamic team of scientists in the in vivo Tumor Biology group within Translational Sciences, playing a leading role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.

The Senior Scientist/In Vivo Lead will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to signal transduction, targeted therapeutics, and epigenetics. The candidate will characterize and develop large and small molecules in close collaboration with partner lines as an integral member of the drug discovery teams. The ideal applicants will employ and develop cutting edge in vivo mouse and human cancer models. The individual will provide technical and scientific expertise in in vivo Pharmacology across ORD to enable target identification, validation, prioritization, and efficient drug discovery. Ideal applicants will be collaborative and team-oriented, possessexcellent communication, leadership and organizational skills, and a commitment to excellence.

Role Responsibilities
  • Work within multi-functional teams to support large and small molecule drug discovery and combination therapy.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Interpretation, presentation and documentation of experiments within an electronic lab notebook, as well as preparation of reports.
  • Written and verbal presentation of results within a multidisciplinary team environment.
  • Develop and characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel therapies.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

Basic Qualifications
  • Ph.D. in Cancer Biology, Immunology or similar scientific discipline.
  • Expertise in in vivo pharmacology and experience with animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry is desired.
  • Expertise with GEMM and humanized models highly desirable.
  • Hands on in vivo (eg: IV, PO dosing, blood/tissue collection, tumor implantation) and ex vivo skills (flow cytometry, western blot, ELISA).
  • Proven ability to make important contributions to cancer biology, immuno-oncology or related fields.
  • Current knowledge of oncology research, drug discovery and development, with emphasis on drug resistance.
  • Ability to follow novel scientific or technological developments, and to implement them in the laboratory.
  • Excellent written and oral communication and presentation skills in English. Proficiency in all common office and scientific software.
  • Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.
  • Must be willing and able to work after hours as needed to ensure study integrity

Other Job Details
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

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