Pfizer

Principal Scientist, BioMedicine Design

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
November 15 2020
Ref
4796883
Position Type
Full Time
Organization Type
Pharma
ROLE SUMMARY

We are seeking a candidate specializing in protein mass spectrometry to work in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. In this role the candidate will investigate, develop, and implement LC/MS and LC/MS/MS based strategies for the structural characterization of recombinant protein biotherapeutics. The candidate will work with project teams to advance biotherapeutic candidates in the discovery space to support the large molecule discovery portfolio across Pfizer.

ROLE RESPONSIBILITIES
  • Provide mass spectrometry-based protein/peptide characterization support for the detailed structural analysis of proteins and conjugates.
  • Elucidation of the major and minor product isoforms from intact protein, subunit, and peptide mapping analyses, as well as identification of unknown (low-level) species using biochemical methods and/or secondary MS techniques.
  • Expected involvement in the design and execution of these studies and the ability to run experiments independently.
  • Responsible for generating top quality mass spectrometry data packages for the characterization of complex biologic candidates such as proteins, antibodies, conjugates, bispecifics, and other engineered biomolecules.
  • Drive technology innovation; evaluate and apply cutting edge technologies and methods for molecular characterization.
  • Work closely with cross-functional teams including therapeutic discovery teams, protein expression and purification groups, biophysics, and development organization to plan and execute deliverables.


BASIC QUALIFICATIONS
  • A PhD in biochemistry, biophysics, or a related discipline preferred with 2+ years in a biopharmaceutical company with experience in protein mass spectrometry.
  • Hands on experience with a wide range of protein mass spectrometry-based technologies and their applications for protein/peptide characterizations, for example, using methods such as LC/MS and LC/MS/MS analysis of biological samples, de novo protein/antibody sequence analysis, peptide mapping, PTM characterization and glycosylation analysis, etc.
  • MS and MS/MS based method development experience is highly desired for implementing more informative and efficient approaches to product characterization.
  • Experience and knowledge in operation of modern mass spectrometry platforms and associated data analysis packages.
  • Experience in maintaining and upkeep of various mass spectrometry platforms such as Thermo Fisher Orbitrap Eclipse, Q-Tof, and Bruker Maxis.
  • Strong communication skills, written and oral and ability to work in team.


PREFERRED QUALIFICATIONS
  • Prior experience in therapeutic protein discovery and biochemistry research.
  • Demonstrated track record of independent research and scientific publications in peer review journals.
  • Experience in glycosylation analysis a positive, but not required.


Other Job Details:
  • Last Date to Apply for Job: December 4, 2020
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

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