Postdoctoral Fellow - T32 Metabolism in Cancer and Diabetes

Duarte, California
January 29 2020
Position Type
Full Time
Organization Type
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions in Dr. Lei Jiang's laboratory which investigates the contribution of metabolic alterations to the development of cancer and diabetes.

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
Funded by the National Cancer Institute (T32CA221709), the program at City of Hope provides exceptionally motivated postdoctoral fellows with scientific knowledge, research training and professional skills in the rapidly growing and interconnected fields of cancer metabolism. The goal of the program is to provide innovative curriculum and mentored research that prepares an elite group of highly motivated fellows to become successful, independent researchers in cancer biology. This Fellow will be mentored by Dr. Jiang, performing cancer-focused, funded, high-impact research in cancer metabolism, and who has a history of mentoring postdoctoral fellows. Required coursework includes a class in Cancer Metabolism. In addition, trainees will participate in journal clubs, data clubs, professional development seminars, monthly luncheons with mentors, national and international scientific conferences, and a yearly Cancer Metabolism Day.

U.S. citizenship or U.S. permanent resident status is required. Individuals from underrepresented minority groups are strongly encouraged to apply.

Fellowships are for up to three years with an institute-supplemented stipend ($61,921 per year plus a full benefit package) and $5,000 for research supplies.

Dr. Jiang's previous study identified a novel NADPH shuttle system supporting ROS defense in the anchorage independent cancer cells (Jiang L, et al. Nature, 2016). The mass spec based stable isotope (NOT radioactive) tracing has been a great tool in the cancer metabolism field, with the advantage of directly studying metabolism in patients (Hensley CT, et al. Cell, 2016). These studies provided additional knowledge to the well-known "Warburg Effect". In addition to generate ATP for energy requirement, metabolism also provides building blocks and controls stress defense. Not only glycolysis, TCA cycle, amino acid and nuclide acid metabolism are all very active in both cultured cancer cells and patient tumors.

Dr. Jiang's lab focuses on the molecular mechanisms regulating central carbon metabolism (citrate) and signaling amino acid (serine) during the development and progress of metabolic diseases. The application of mathematical bioengineering based modeling prediction and experimental mass spec based metabolic tracing will provide a better understanding of the metabolic rewiring in diabetes, cancer and other diseases.

A motivated postdoc is encouraged to join Dr. Jiang's laboratory, a new addition to the Diabetes & Metabolism Research Institute, headed by Arthur D. Riggs, Ph.D., a pioneer in the field renowned for his work on synthesizing the first man-made gene and using synthetic genes to produce human insulin.

Basic education, experience and skills required for consideration:
  • PhD in biochemistry, molecular or cellular biology; Applicants must have a completed doctoral degree before starting the fellowship program (all Ph.D. coursework must be completed, final orals must be passed and the dissertation signed).
  • No more than two years postdoc experience.
  • Excellent written and verbal communication.
  • Determined and self-motivated scientist.
  • Good publication record in metabolism, cancer or diabetes.
Additional Information:
  • Please submit a curriculum vitae and publication list directly to .
  • For more information about Dr. Jiang's research, please click here .
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

Similar jobs

Similar jobs