PhD Student (Single-Cell Genomics, CRISPR, Functional Genomics)

Pittsburgh, Pennsylvania
Competitive salary and fringe benefits
November 02 2020
Position Type
Full Time
Organization Type
Job Type
PhD Studentship

The Mathys Group develops and applies new functional genomics tools and methodologies to systematically decipher the molecular regulatory circuitry that controls the biology of brain cells in health and disease.

With nearly one hundred billion neurons, which are connected by trillions of synapses, the human brain is arguably the most complicated biological structure in the known universe. How the brain is built and functions remains one of the greatest mysteries in science and understanding what causes dysfunction of the brain in the case of disease poses one of the greatest challenges in medicine. The research in our laboratory aims towards contributing to a better understanding of this enigmatic organ in health and disease focusing on the molecular mechanisms underlying Alzheimer’s disease. We use a multi-disciplinary approach, combining single-cell genomics, genome engineering, pooled genetic screens, and computational analysis, to dissect the inner workings of brain cells and their dysfunction in Alzheimer’s disease.

A major focus of our research are the cellular and molecular mechanisms underlying Alzheimer’s disease. The goal is to understand why some people age in a healthy way without cognitive impairment and why others do not and develop dementia? We hope that understanding the underlying cellular and molecular root causes of Alzheimer’s disease will facilitate the development of protective or preventive therapeutic strategies that promote healthy aging.

Interested in joining us?

The Mathys Lab is always looking for talented scientists to join our team, from PhD students to Postdocs to staff scientists. If you are passionate about basic scientific research and innovation, motivated, ambitious, and curious, we want you to be part of our team.

We invite interested and highly qualified candidates with a strong commitment to basic science to apply. Please submit (1) your CV, (2) a cover letter outlining your research interests, and (3) contact information for two references to Dr. Hansruedi Mathys at

For information about Hansruedi Mathys' lab, please go to:

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