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Lab Head, Vector Biology

Employer
GSK
Location
Rockville, MD
Salary
Competitive
Closing date
Nov 7, 2020

View more

Discipline
Life Sciences, Biology
Job Type
Academic Dean/Dept. Head
Organization Type
Pharma
The Vector Biology group at the US Research and Development Center, GSK Vaccines, is responsible for designing, characterizing and optimizing vector platforms for vaccine delivery, with a focus on mRNA vaccines, and for understanding the interactions between RNA vaccines and innate immune responses.

We are looking for a highly motivated scientist with a proven record in utilizing the most up to date molecular and cell biology tools to design the best vector-based vaccines, to provide expertise in vaccine development for GSK projects.

Responsibilities:
  • To provide expertise in the areas of Vector Biology and Innate immunity to guide the selection of new vaccine platforms.
  • Apply the state-of-the-art molecular biology and molecular virology, particularly RNA virology, to engineer viral agents, drive the preclinical development of vector-based vaccine platforms (particularly the RNA platform)
  • Determine mechanism of mRNA-based antigen expression and presentation to adaptive immune system
  • Elucidate the contributions of the mRNA molecule and lipid delivery system on innate immune activation, cell recruitment, and inflammation
  • Provide Virology expertise to GSK Vaccine projects.
  • Provide effective and inspiring leadership with an enterprise mindset, ensuring support to professional development and qualification of staff.
  • Ensure the team use cutting edge technologies and ideas to deliver best preclinical expertise to GSK vaccine projects in discovery, development, and life cycle management.
  • Ensure that the objectives of the team are aligned with R&D and business priorities and team activities are designed and delivered according to project needs.
  • Takes full accountability of management tasks for the team and meet data integrity and quality expectations.
  • Ensures the team delivering assigned activities in the most efficient and resource conscious manner; drives innovation to establish technology in the lab to enhance data quality and resource utilization.
  • Possesses strong scientific leadership to enable collaboration with key scientific internal and external stakeholders.
  • Participate in IP and regulatory filings and publishes in peer reviewed journals
  • Manage a team of 5-10 scientists.
  • Supervise PhD students and postdoctoral fellows as needed.
  • Accountable for the management monitoring of the laboratory, ensuring that compliance with the GSK Environment, Health and Safety standards are an integral part of the operations and culture.


Basic Qualifications:
  • PhD degree in life sciences with at least 10 years of experience in a related biotechnology field.
  • Experienced in the fields of Virology, Innate Immunity, and viral interactions with the host.
  • Experience in the most current bioinformatics tools to design new RNA vaccine candidates
  • Strong track-record of scientific publications in peer-reviewed journals.
  • Fluency in English, spoken and written.


Preferred Qualifications:
  • Prior experience with RNA viruses or viral vector-based vaccine platforms is preferred.
  • Experienced in the development of RNA based vaccines
  • Experience with alphavirus replication and/or alphavirus as vectors highly desirable
  • Experience on RNA structure and/or knowledge of innate immune responses


Please use the cover letter to highlight how you meet the competencies for the role. Your cover letter along with your CV will be used to assess your application. Thanks for your interest in this opportunity.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness


*LI-GSK

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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