Postdoctoral Fellow - Ribosomal RNA Transcription in Hematopoiesis - University of Pennsylvania

A full-time postdoctoral position is available in the Paralkar Lab in the Division of Hematology-Oncology and the Abramson Family Cancer Research Institute at the University of Pennsylvania for an NIH-funded project to study ribosomal RNA transcription in hematopoiesis.

Our laboratory combines cutting-edge molecular biology approaches with in vitro and in vivo models of hematopoiesis and leukemogenesis to dissect how key hematopoietic transcription factors bind to ribosomal DNA and fine-tune the transcription of ribosomal RNA, the most abundant RNA in the cell, to meet precise ribosome requirements of diverse blood cell types. This work is funded by a 5-year R35 grant from NIGMS (NIH). Experimental techniques used in our work include: Human and mouse hematopoietic and leukemia models, chromatin studies including ChIP and chromosomal looping assays, FISH and nucleolar imaging, chromatin proteomics, high-throughput sequencing approaches including ATAC-Seq, ChIP-Seq, RNA-Seq, and a variety of molecular assays.

Candidates must have an MD, PhD or MD/PhD degree, and proficiency with molecular biology and cell biology techniques. Experience in the epigenetics/chromatin/transcription research space is strongly favored. Experience with mouse hematopoiesis or mouse models of leukemia is a plus, but is not required.

Please send a CV, a brief cover letter summarizing past research and career goals, and the names and contact information of three references to: vikram.paralkar@pennmedicine.upenn.edu

Website: https://www.med.upenn.edu/apps/faculty/index.php/g348/p8341218