Sr Research Scientist

Location
Newark, Delaware (US)
Salary
Salary commensurate with experience.
Posted
October 23 2020
Position Type
Full Time
Organization Type
Healthcare/Hospital

Req # JR53996 - Sr Research Scientist - Preclinical Research Lead - Gene Editing Institute

https://careers.christianacare.org/jobs/Sr_Research_Scientist_-_Preclinical_Research_Lead_-_Gene_Editing_Institute/Newark_Delaware/101/229506/

The Gene Editing Institute is the only research institute of its kind in the nation based within a community health care system. Led by gene editing pioneer, Eric Kmiec, Ph.D., and based in ChristianaCare's Helen F. Graham Cancer Center & Research Institute, the Gene Editing Institute is a worldwide leader in gene editing biomedical research in cancer and other inherited diseases, and the only one working in the same space with oncologists, genetic counselors and patients, bringing translational research from basic science to patient treatment to an entirely new level.

ChristianaCare is currently seeking a Sr. Research Scientist - Preclinical Research Lead for the Gene Editing Institute at our Helen F Graham Cancer Center.  The Sr. Research Scientist I will lead preclinical non-small cell lung cancer (NSCLC) research projects in the Oncology group and in collaboration with other teams within the Gene Editing Institute. The Oncology group in the Gene Editing Institute focuses on the development of new, targeted delivery system utilizing AAV-CRISPR/Cas to treat NSCLC in combination with chemotherapy. As a group leader, the Senior Research scientist will expand current preclinical research built on the proof-of-concept studies to successfully file INDs with FDA. The ideal candidate will have advanced and hands on expertise in CRISPR gene therapy and extensive industrial experience in leading a team of scientists to bring about tangible outcomes in timely delivery of therapeutic products.

Other responsibilities include:

  • Lead preclinical research in NSCLC gene therapeutic drug development
  • Develop and implement proof-of-concept and preclinical research in other solid tumor gene therapy
  • Hands on laboratory research in cancer biology, CRISPR technology, AAV biology and other delivery system
  • Manage the overall progress of the preclinical programs to be aligned with set timelines
  • Identify and manage Contract Research Organizations for timely execution of projects.
  • Work with cross-functional team to support the IND submissions
  • Take Lead role in writing or contracting out nonclinical reports to include in Module 4 of the IND
  • Support pIND and other meetings with the FDA

Requirements:  PhD in oncology, molecular biology, cell biology, biochemistry, or a closely related field. Six to ten years of pharmaceutical industry experience in gene therapeutic development, preclinical and clinical researches. Must be proficient in CRISPR gene therapeutic development, AAV delivery (and/or nonviral vector delivery systems), CRISPR technology and its clinical application, cell-based models and in utilization of murine models, and performing cell biology, biochemistry, and molecular biology techniques.

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