Post-Doctoral Research Fellow, Innate Immunity

Location
Seattle, Washington State (US)
Salary
Based on experience
Posted
October 16 2020
Ref
17771
Position Type
Full Time
Organization Type
Non-Profit

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here. 

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   
  


Post-Doctoral Research Fellow positioning is immediately available with Dr. Anthony Rongvaux, Ph.D. at Fred Hutchinson Cancer Research Center. The Rongvaux Lab uses state of the art humanized murine models to studies innate immune responses specific to the human species. This research has applications in both cancer and infectious disease modalities, and ranges from fundamental research to the development of novel drugs and immunotherapies. 

 

Responsibilities

Innate immunity and cancer 
Most cancer deaths happen because the cancer has spread to distant sites throughout a patient’s body—a phenomenon called metastasis. Why does metastasis occur, and how can we stop it to save lives? 
  
It has been known for over three decades that a high density of macrophages in the tumor microenvironment correlates with metastatic progression and poor patient survival. However, the mechanisms by which macrophages support cancer remain incompletely understood. Our lab has developed unique humanized murine models for immuno-oncology studies. With these models, we have identified physiologically relevant macrophage populations involved in tumor support. We are currently studying the fundamental biology of these macrophages, and developing new therapeutic agents to target them. 
  
Innate immunity to HIV infection 
Over 35 million people are living with HIV worldwide. About 40% of them don’t have access to antiretroviral therapies, resulting in over half a million deaths annually. 
  
Acute HIV infection induces a rapid inflammatory response, characterized by the production of large amounts of cytokines. However, this immune response is ineffective at controlling the virus. As a consequence, the virus can establish chronic infection and, if not treated, progress to a lethal disease. Understanding why the natural immune response to HIV infection does not confer protection, could help us design more effective vaccine strategies. 
  
Using state of the art humanized murine models, single-cell RNA sequencing and genome editing, the postdoctoral fellows will study the mechanisms by which the immune system detects, and responds to transformed or infected cells. Understanding how the immune response fails to restore homeostasis is a prerequisite to design novel therapeutic or vaccine strategies. 

 

Qualifications

  • Applicants will have a recent PhD in Immunology, Immuno-oncology, Cellular & Molecular Biology or a closely related field 
  • The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, and animal studies. Desirable skills include bioinformatics analysis, scientific writing and presentations 
  • Strong interest in immunological applications in cancer and/or HIV infection. 
  • To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by at least one first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced, collaborative and dynamic environment. These positions are suited to someone who enjoys mastering new skills, multitasking and working in a multiple team environment 

 

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer.  We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected.  We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class.  We are an Affirmative Action employer.  We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our HR Operations at HRops@fredhutch.org or by calling 206-667-4700.

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