Postdoctoral Positions in Protein Biophysics and Structural Biology

Case Western Reserve University
Cleveland, Ohio (US)
competitive, $50k+ (based on experience)
October 16 2020
Position Type
Full Time
Organization Type
Job Type

We are looking to add postdoctoral co-workers to our interdisciplinary team as new funding has been awarded to our laboratory for the investigation of the role of a transmembrane receptor in interacting with kinases and Alzheimer proteins, as well as several other systems (an IDP, a peripheral membrane protein and an enzyme) in collaboration with leading local-international laboratories. Our interest is to understand the disease associated protein interactions at the protein biophysics, biochemical, structural and protein dynamics level. 

We principally use solution NMR, not so much for protein structure determination but more for protein surface and interaction site mapping and for the characterization of protein dynamics and conformational change. The projects will also involve amide hydrogen exchange on a Waters mass spectrometer dedicated to HX-MS, and employ NMR methyl relaxation and molecular dynamics simulation as additional tools. The North East Ohio High Field NMR facility consists of a 600 MHz, 700 MHz, 800 MHz and a 900 MHz Bruker spectrometers. With the recent installation of a Titan Krios at Case Western Reserve University there is also considerable interest to apply cryo-EM to our systems and postdocs will be able to learn from/work with local collaborators and facility manager.

We are looking for talented and highly motivated coworkers, who aim to become academic- or industry project group leaders (> ½ of the previous postdocs accomplished this goal). Prior experience with protein purification is a must and with structural biology (protein NMR or x-ray crystallography) is highly desirable. The Buck laboratory provides a stimulating but friendly working environment. The Medical School of Case Western Reserve University is highly rated overall in the US (~ 16th. in terms of NIH funding for 2020) and Cleveland is a pleasant but affordable place to live with excellent educational, medical and cultural institutions. The starting date is as soon as possible but this project details are negotiable and the salary is competitive, based on experience. Please send your resume, overview of your scientific interests and career goals as well as contact details of three referees able to provide references by e-mail to