Research Associate II

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary:
Our group in the Systems Biology Department in the Beckman Research Institute at the City of Hope is interested in discovering novel genetic and epigenetic regulations and deciphering their underlying molecular mechanisms in normal developmental processes (e.g., hematopoiesis) and tumorigenesis (e.g., leukemogenesis). DNA/RNA epigenetics and translational research are our research focuses in the coming years. The ultimate goal of the laboratory is to translate our laboratory discoveries into the development of effective novel therapeutic strategies to treat cancers (especially leukemia) in clinic. The successful candidate will assist laboratory research by providing technical assistance, preparing and arranging reagents, managing mouse colonies, ordering and inventory of stocks.

Key Responsibilities include:

• General lab maintenance and ordering (i.e. restock lab reagents, maintain supplies stocks)
• Mouse handling includes husbandry, injections including drug-treatments, proficiency in collection of submandibular blood of mice
• Bulk plasmid purification, PCR, gel electrophoresis, genotyping, Western blotting
• Adherent and suspension cell culture maintenance
• Test out new reagents/products for potential lab use
• Additional consideration for applicants with previous clearance for animal irradiation and/or previous experience in flow cytometry for quantification of xenograft engraftment
• Techniques may include, but are not limited to basic molecular biology, biochemistry, aseptic techniques, immunofluorescence, immunohistochemistry, and microscopy. A highly qualified Research Technician may serve as the lab manager.

Qualifications
Basic education, experience and skills required for consideration:

• Bachelor's degree with 2 years of experience or Master's with 1 year of experience.
• Experience with genetic mouse models, cellular and molecular biology techniques is a big plus

Additional Information:

• For more information on Dr. Jianjun Chen's research please visit, here .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.