Research Investigator - Mouse handling

Houston, Texas
October 12 2020
Organization Type
Research Investigator

The Department of Thoracic/Head and Neck Medical Oncology staff directly responsible for patient care is comprised of 20 physicians, 13 research nurses, two inpatient mid-level providers and 10 outpatient mid-level providers. Our physician team includes nine physicians who care only for thoracic medical oncology patients in the Thoracic Center, one medical oncologist who treats head/neck patients in the Head/Neck Center and 10 medical oncologists who treat both lung cancer and head/neck cancer patients in those respective outpatient clinic areas.


To design, organize and perform research activities.

-Designs, organizes and performs animal work and protocols.
-Performs animal surgery.
-Organizes, coordinates and participates in scientific research projects under the direction of a professional staff member.
-Functions in a separate and independent manner in the design and initiation of research experiments.
-Designs, develops, or adapts equipment used in experiments or research to obtain desired results.
-Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems.
-Supervises the use of laboratory equipment and implements safety procedures. Monitors use of shared equipment.
-Responsible for providing laboratory services, tissue culture, processing research samples, and/or cataloging samples as required, especially on translational aspects of clinical protocols.
-Compiles, writes and submits project results to superiors.

To maintain good, detailed experimental records and analyze data.

-Maintain an up-to-date, organized, and legible laboratory journal that records all experiments in detail
-Evaluate resulting research data by utilizing image analysis system and/or microscope to analyze data and examine results

To work closely with other staff members.

-Maintain good working relationship with other researchers and technicians
-Train and supervise new technicians and other laboratory personnel in proper laboratory techniques, the use of laboratory equipment, and safety procedures
-Explain to staff members the scientific protocols currently being employed in the laboratory

To assist with dissemination of results and analyses.

-Present findings of the research project to professional groups
-Prepare scientific data and documents for publication

Maintain and Develop genetically engineered mouse models (GEMMs) of NSCLC

Maintain and breed existing GEMMs of inducible models of NSCLC including various KRAS mutant models, KRAS/LKB1 mutant models, and EGFR mutant models. Induce expression of transgenes through administration of doxycycline or adeno-cre via intrathoracic injection. Maintain detailed records of breeding schemes, genotype of progeny, and tumor development. Work with Vet Med staff to perform imaging to visualize tumor development. Perform histological studies to validate tumor development. Work with the PI and scientists in the lab to prioritize expansion of GEMMs for upcoming experiments.

Develop Novel GEMMs

Work independently to develop novel GEMMs as instructed by the PI. Conduct all procedures in accordance with IACUC regulations. Develop novel cell lines from tumors derived from GEMMs. Work with Vet Med when new GEMMs need to be cryopreserved. Integrate CRISPR technology into GEM models to enable more rapid alterations to be introduced into GEMMs.

Expertise in vitro and in vivo assays

Perform various injections in mice (including oral gavage, IP injections, IV injections, subcutaneous injections. Administer anesthesia to mice and perform survival surgeries including tumor resection, PDX implantations and orthotopic injections.The individual will work with existing members of the lab animal team and should be able to communicate well with others. Perform immunohistochemistry and PCR.

Other duties as assigned

Education Required: Bachelor's degree in one of the natural sciences or related field.

Experience Required: Five years of experience in scientific or experimental research work. With preferred degree, three years of required experience.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

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