Post-Doctoral Scientist

Location
Palo Alto, California
Salary
See Job Description
Posted
October 09 2020
Position Type
Full Time
Organization Type
Academia

Post-Doctoral Scientist at Stanford University:

Shamloo laboratory at Stanford University is seeking a Post-Doctoral fellow with pharmacology, neuroscience, or immunology background for training in a translational neuroscience program.

Project Summary:

Selectively neuronal vulnerability in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurocognitive disorders is an understudied subject that needs further investigation. The selective neuronal circuit degeneration is proceeding impairment in learning and memory, emotional behavior, and higher-order cognitive processing. Our identified targets play a critical role in regulating both neuronal function and neuroinflammation. The projects will aim to study two targets and their mechanistic pathways, leading to a selective neuronal vulnerability in selective brain regions and its acceleration in pathological conditions in neurocognitive disorders such as Alzheimer’s disease and Parkinson’s disease.

Aim:

Key fundamental goals of projects and students are to study: 1) Identified mechanistic pathways and their role in selective neuronal vulnerability in the brain and its acceleration in pathological conditions, 2) Identification of the cellular targets for prevention and protection of the vulnerable cell populations in the brain. Innovative methods such as whole-brain quantitative 3-D imaging techniques will quantify regional microgliosis, neuroinflammation, and neurodegeneration to discover the vulnerable regions within the context of interconnected networks undergoing chronic persistent neuroinflammation. Unbiased genomic and proteomic techniques will identify novel cellular pathways underlying selective neuronal vulnerability.

The Post-Doctoral scientists/students will aim to understand the mechanistic pathways associated with two identified targets in neuronal cell death and work on the identification of other cellular targets for the prevention and protection of these vulnerable cell populations. Innovative whole-brain quantitative 3-D imaging techniques will quantify regional microgliosis, neuroinflammation, and neurodegeneration, as well as unbiased genomic and proteomic techniques, which will be utilized for the identification of novel cellular pathways underlying selective neuronal vulnerability projects.

The Post-Doctoral scientists/students enrolled in this program will interact with and collaborate heavily with translational neurobiologists in the laboratory studying diverse CNS disorders using pharmacological, mechanistic, and behavioral tools.

Qualifications:

  • Applicants should have PhD degree in pharmacology, neurobiology, pathology, neuroendocrinology or related science.
  • Good working knowledge/interest in molecular pharmacology, molecular biology, pathology and biochemistry.
  • Proficiency with experimental approaches common to the field. (e.g. mammalian cell culture, qRT-PCR, ELISA, Western blot, immunofluorescence staining, sectioning, and microscopy, etc.)
  • Experience working with animals is preferred.
  • Demonstrate ability to independently design and execute experiments, interpret data and identify appropriate follow-up strategies. 
  • Publication record.

Funding:

  • Not required for the first two years.

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