Postdoctoral Fellow or Staff Scientist - CAR T Cell Immunotherapy

Duarte, California
January 29 2020
Position Type
Full Time
Organization Type
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A position is available for a motivated and creative person to work on a project concerned with, but not limited to, using advanced light microscope imaging techniques to understand and surmount barriers limiting application of CAR T cell immunotherapy to glioblastoma and other primary and metastatic brain tumors (Akhavan et al., "CAR T cells for brain tumors: Lessons learned and road ahead" Immunol Rev. 2019). These challenges include the immunosuppressive microenvironment, T cell persistence and exhaustion, and tumor antigen escape.

The position involves designing and executing immunochemical studies incorporating multiplexed techniques including immunohistochemistry, immunofluorescence and imaging mass cytometry, coupled with analyses using high dimensional imaging software such as Visiopharm, to probe an existing and expanding library of annotated patient tumors.

The successful applicant will work independently in collaboration with two PIs with a long history of collaboration (Drs. Michael Barish and Christine Brown) along with the diverse and talented members of their laboratory teams. Required is a doctoral-level degree (PhD or MD) in immunology, tumor biology, or other relevant area, along with experience in microscopy and quantitative image analyses. An important criterion will be the demonstrated ability to critically interpret experimental results, and present data in a cogent and meaningful manner.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or immunology, tumor biology, biomedical sciences, or a related discipline is required.
Additional Information:
  • Please send current CV and one or two significant publications to Michael Barish, PhD at for consideration.
  • Title and compensation will be at a level commensurate with experience.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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