The Ke Lab is seeking a postdoctoral associate at The Jackson Laboratory in Bar Harbor, Maine. The lab focuses on RNA, a central node of genetic information flow from DNA to protein. Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.) To learn more about the Ke Lab, please visit: https://www.jax.org/research-and-faculty/faculty/shengdong-ke.
The successful candidate will be encouraged to develop an independent research program using a broad array of resources and expertise available to the lab (https://www.jax.org/research-and-faculty/tools/scientific-research-services). Exceptional postdoctoral candidates will have the opportunity to apply for the title of JAX Postdoctoral Scholar, an internal award addressing the national need for research scientists who are accomplished in the broadly defined fields of genetics and genomics. The award includes an independent research budget, travel funds, and a salary above standard postdoctoral scale.
- Ph.D. or M.D. degree, with background in biochemistry, molecular biology, stem cell or cancer biology, biotechnology, neurosciences, immunology, or computational biology,;
- A good publication record and excellent communication skills; and
- Skills in quantitative programming or biochemistry are preferred, but not required.