Chemistry Group Leader - Center for Protein Degradation

Dana Farber Cancer Institute
Boston, Massachusetts
commensurate with experience
August 13 2020
Position Type
Full Time
Organization Type
Job Type

Chemistry Group Leader - Center for Protein Degradation

Dana-Farber Cancer Institute

Boston, MA


Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Fischer and Gray.  The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets.   This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions.



  • Lead medicinal chemistry at the Center for Protein Degradation in the Dana-Farber Cancer Institute.
  • Responsible for managing the CPD chemistry team and external CRO synthesis
  • Play a key role in shaping the scientific strategy of the center, working closely with the Director and other discipline group leaders.
  • Work with the Portfolio Manager and Financial Manager to ensure operational activities align with portfolio needs to expedite project delivery.
  • Drive a culture of urgency and scientific excellence with a focus on therapeutic impact.
  • Present and publish CPD innovations externally.



  • PhD in chemistry required and ideally 5+ years of pharma/biotech medicinal chemistry experience preferred
  • Exceptional scientific background with a track record of delivery – able to provide sophisticated solutions to complex problems
  • Expert in applying medicinal chemistry techniques and analyses to advance molecular design
  • Experience of structure-based drug design
  • Strong management skills – effectively manages the performance of the team, and their development, to maximize team impact
  • Drives change, challenges dogma, thrives in ambiguous situations
  • Collaborative mindset – capable of working with all stakeholders and project teams to ensure portfolio progresses
  • Excellent presentation skills


For more information, or to apply, please visit:


About Dana-Farber:

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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