POSTDOCTORAL POSITION AVAILABLE

Location
Indianapolis, Indiana
Salary
See Job Description
Posted
July 20 2020
Organization Type
Academia

POSTDOCTORAL POSITION AVAILABLE

Cellular signaling and regulation of gene expression

​We are accepting applications for a postdoctoral fellow interested in the study of cellular signaling and the regulation of gene expression in the protozoan parasite Toxoplasma gondii. Toxoplasma is an opportunistic pathogen that causes severe disease in congenitally infected infants and immune compromised patients. Toxoplasma is a significant clinical challenge because the parasite converts into a latent tissue cyst form that evades immunity and current drugs. The tissue cysts are central to pathogenesis, transmission, and behavioral changes in the host.

Our laboratory seeks to solve this clinical problem by obtaining a better understanding of the mechanisms driving tissue cyst formation. We use state-of-the-art multi-disciplinary approaches to interrogate how the parasite alters translation and reprograms its genome to convert to the latent stage of infection.

The successful applicant will contribute to exciting projects examining the myriad ways gene expression is regulated in the context of cyst formation. This includes study of multiple mechanisms including transcription, epigenetics, epitranscriptomics, and translational control. Our long-term goal is to identify novel points of therapeutic intervention that will thwart the development and maintenance of Toxoplasma tissue cysts.

This is an NIH-funded position in the laboratory of Bill Sullivan (http://www.sullivanlab.com/). The position requires a Ph.D., expertise in cell/molecular biology or biochemistry, and excellent communication skills (speaking and writing English). Submit CV and contact information for three references to wjsulliv@iu.edu

Our laboratory is a part of the “BIP” (Biology of Intracellular Pathogens) group at the Indiana University School of Medicine (IUSM): http://wjsulliv.wix.com/bipatiu. Located in downtown Indianapolis, IUSM is the largest medical school in the US and boasts an outstanding intellectual atmosphere and core facilities. IUSM was nationally ranked in the Top 30 Best Places to Work for Postdocs. IUSM is an equal opportunity employer.

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