Postdoctoral Research Fellow in the Department of Pathology

Boston, Massachusetts (US)
Salary commensurate with experience.
July 17 2020
Dr Sabina Signoretti
Organization Type


Postdoctoral Research Fellow in the Department of Pathology at Brigham and Women’s Hospital/Harvard Medical School

Immunotherapy with immune checkpoint inhibitors (e.g. anti-PD-1/PD-L1 agents) has demonstrated clinical efficacy in metastatic renal cell carcinoma (mRCC). Unfortunately, only a subset of mRCC patients responds to these agents. To guide further clinical development of immune checkpoint inhibitors in kidney cancer, we aim to 1) develop and validate tissue-based predictors of drug response using both genomics approaches and in situ analyses (e.g. multiparametric immunofluorescence); 2) understand the mechanism of action of PD-1/PD-L1 blockade to facilitate the development of highly active combination regimens.

Requirements: We are seeking a highly motivated applicant with an M.D. and/or Ph.D. in biology/immunology/molecular biology and strong laboratory experience in cell and molecular biology. Candidates with a background in bioinformatics or pathology are highly preferred. Excellent written and oral communication skills are required.

If interested, please send a cover letter, CV and three references to:

Sabina Signoretti M.D.
Department of Pathology
Brigham and Women's Hospital
Thorn Building 504A
75 Francis Street
Boston, MA 02115
617-525-7437 (phone)

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