Postdoctoral Research Fellow in the Department of Pathology
Postdoctoral Research Fellow in the Department of Pathology at Brigham and Women’s Hospital/Harvard Medical School
Immunotherapy with immune checkpoint inhibitors (e.g. anti-PD-1/PD-L1 agents) has demonstrated clinical efficacy in metastatic renal cell carcinoma (mRCC). Unfortunately, only a subset of mRCC patients responds to these agents. To guide further clinical development of immune checkpoint inhibitors in kidney cancer, we aim to 1) develop and validate tissue-based predictors of drug response using both genomics approaches and in situ analyses (e.g. multiparametric immunofluorescence); 2) understand the mechanism of action of PD-1/PD-L1 blockade to facilitate the development of highly active combination regimens.
Requirements: We are seeking a highly motivated applicant with an M.D. and/or Ph.D. in biology/immunology/molecular biology and strong laboratory experience in cell and molecular biology. Candidates with a background in bioinformatics or pathology are highly preferred. Excellent written and oral communication skills are required.
If interested, please send a cover letter, CV and three references to:
Sabina Signoretti M.D.
Department of Pathology
Brigham and Women's Hospital
Thorn Building 504A
75 Francis Street
Boston, MA 02115