Postdoctoral Researcher (100%)

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking an experienced and highly motivated Postdoctoral Researcher to join the Single-Cell Genomics Platform lead by Simone Picelli and participate in the development and implementation of new single-cell sequencing methods at IOB.

IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.

The advent of single-cell genomics represents a turning point in cell biology. For the first time we are able to assay the expression level of every gene in the genome across thousands of individual cells, in a single experiment. Although almost 10-years old, single-cell genomics is still a field in its infancy, with many experimental and computational advances needed to achieve its full potential.

The main goal of the Single-Cell Genomics Platform is to address these limitations by developing and implementing state-of-the art single-cell genomics methods with superior sensitivity, capable of assaying multiple features from the same cell (multi-omics approaches), all while increasing sample throughput and streamlining the processes to contain the costs. Our final and by far most important goal is to eventually translate this knowledge into a better understanding of disease states, their implications for therapeutics and help developing tailored treatment for the patients.

Your responsibilities

• Designing, conducting, analysing and troubleshooting complex single-cell experiments
• Developing and implementing new single-cell genomics protocols (plate- and emulsion-based) in collaboration with IOB research groups, with a special focus on ophthalmology
• Developing and optimizing Spatial Transcriptomics methods
• Planning, executing and interpreting bioinformatic analyses of primarily single-cell RNA sequencing data (10X Genomics and Smart-seq2) and single-cell epigenomics data (ATAC-seq, 10X Genomics)
• Automatizing newly developed and existing methods on state-of-the-art robotic platforms

Requirements

• PhD degree in molecular biology, biomedical science, biotechnology or a related field
• Minimum of 5 years research experience in Genomics. Previous experience in the single-cell field will be highly valued
• Knowledge of Python/ R and bash as well as experience with Github or related resources
• Knowledge of liquid handling robotic platforms is an advantage but training will be provided
• Highly organized, detail-oriented and creative thinking
• Excellent written and verbal communications skills
• Fluency in English is a requirement, fluency in German is an advantage

We offer

• Highly competitive conditions in a dynamic and international research community in Basel
• IOB is an equal-opportunity employer with family-friendly work policies

Application / Contact

Interested candidates should submit their application documents as a single PDF file to jobs@iob.ch by November 20^th, 2019. Please indicate the position you are applying for by writing the reference number (IOB039) on the subject line.

For further information, please visit our website www.iob.ch or contact Josephine Puttkammer (josephine.puttkammer@iob.ch / +41 79 852 75 32).