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Postdoctoral Fellowship

Employer
National Cancer Institute, NIH
Location
Frederick, Maryland (US)
Salary
Starts at $55,700, plus health insurance
Closing date
Jan 7, 2020

View more

Discipline
Life Sciences, Molecular Biology, Structural Biology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
Govt.

Department of Health and Human Services (DHHS)

National Institutes of Health (NIH)

National Cancer Institute (NCI)

Center for Cancer Research (CCR)

A postdoctoral position is available in The Kinase Complexes Section (KCS), Structural Biophysics Laboratory (SBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Frederick, MD.  The candidate will perform basic research in molecular biology/structural biology/biochemistry. 

The KCS group studies the structural and mechanistic basis of kinases that are closely related to human cancers and many other diseases. Our focus is on oncogenic kinases (including ALK, BRAF, Leucine Rich Repeat Kinase and PKA). We have also developed new collaborations within the CCR involving projects with propensity for translational application to the clinic, including the study of nucleosome complex and Microprocessor complex. We apply a combination of biochemical and structural (single-pai1icle cryo-electron microscopy and X-ray crystallography) approaches to reveal the molecular mechanisms of such multi-component biological complexes and help to provide new strategies for therapeutic targeting.

The research of the group is supported by the collaborative and interdisciplinary NIH intramural program, which includes more than 1100 labs and provides state-of-the-art equipment in structural biology, biochemistry, and biophysics. These core facilities are supported by Ph.D. level staff and offer hands-on training. In addition, NIH is committed to the continuing education and career development of its research staff through numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES). There are also opportunities for intramural career transition funding (K grants).

Interested candidates must have a Ph.D. or M.D. degree with less than 5 years of postdoctoral experience.  Applicants must have a strong background in molecular biology, structural biology, biochemistry, or a related discipline. The candidate should have good oral and written skills in English. The candidate should be skilled in at least one of the following areas; Biochemistry and molecular biology (experience in protein purification from different expression systems and/or enzymology etc.); Electron microscopy (experience in cryo-EM sample preparation and digital image processing). We have excellent access to high-end microscopes (Titan Krios equipped with K2 camera and Arctica equipped with K3 camera); testing microscopes are available, and the computational infrastructure is setup; Crystallography (experience in protein crystal structure determination). We have excellent access to Synchrotron beamline and in-house SAXS core.

The candidate must be highly motivated to participate in rigorous and innovative research programs and possess excellent work ethic and team spirit: be able to work independently and efficiently and collaborate closely with members of the group and other labs on joint projects.

The research group is supported by the collaborative and interdisciplinary NIH intramural NIH offers competitive salary and comprehensive health insurance.  Appointments will be one year initially and renewable up to a total of 3-5 years based on performance.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation. 

Interested applicants should send a cover letter indicating preferred starting date, a brief description (1-2 pages) of past research, CV, and contact information for at least three references via email to Ping Zhang, Ph.D.: ping.zhang@nih.gov,  (301-228-4092).  More information about KCS can be found at: https://ccr.cancer.gov/Structural-Biophysics-Laboratory/ping-zhang Structural Biophysics Laboratory is located on the Frederick campus of NCI in Maryland, USA.

DHHS, NIH, and NCI are Equal Opportunity Employers

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