Sr./Research Associate, In Vivo Pharmacology, Oncology TA Research

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
November 06 2019
Ref
R1873
Organization Type
Biotech
The Role:

The Moderna Oncology team is looking for a talented and motivated in vivo pharmacologist to focus on validating new mRNA based therapies in cancer. The successful candidate will primarily work with in vivo tumor models and be responsible for validating the in vivo pharmacology and therapeutic utility of novel mRNA therapeutics. Applicants should be great team members and have a track record of independent research accomplishments. The ability to effectively communicate with internal team members is required.

Here's What You'll Do:
  • Perform and/or take lead on routine in vivo pharmacology studies (including tumor growth kinetics, tolerability, anti-tumor efficacy, formulations screens, in vivo expression, biodistribution, and pharmacokinetic and pharmacodynamic studies)
  • Organize and perform all tasks associated with routine in vivo pharmacology studies (including tissue culture, preparation and identification, implantation of cancer cells/materials, preparation of test articles, dose administration and necropsy and tissue collection for downstream processing).
  • Develop new mouse models of cancer to test various messenger RNA therapeutics
  • Study data collection with StudyLog and analysis with GraphPad Prism software
  • Matrix with internal teams on initial testing of mRNAs
  • Adhere to all Moderna IACUC protocols, policies and guidelines
  • Deliver reproducible results under aggressive timelines
  • Independently organize experiments
  • Analyze, interpret and present data
  • Faithfully document scientific work; contribute to reports and presentations


Here's What You'll Bring to the Table:
  • B.S. in a biological science with 2+ years' relevant full-time hands on in vivo experience; M.S. with 1+ year of relevant full-time hands on in vivo experience
  • Solid background in tumor biology and pharmacology
  • Expertise in the following:
    • Pharmacological agent administration via iTu, IV, IP, SC, IM and PO dosing routes
    • Implantation of cancer cell lines and tumor-derived material in SC space
    • Collection of serum/plasma/whole blood, tissues, primary tumor material and metastases
    • Mouse anesthesia/analgesia
    • Animal surgeries
    • Whole animal and ex vivo imaging
  • Tissue/cell culture expertise:
    • Cell passaging, archiving for implant
  • Effective oral and written communication skills
  • Preferred to have expertise in one or more of the following:
    • Development of advanced local, systemic, disseminated, or orthotopic syngeneic tumor models
    • Expertise in performing anti-tumor efficacy and PK/PD studies across multiple syngeneic tumor models
    • Experience working with patient-derived xenografts
    • Bioluminescent/fluorescence imaging using an IVIS Spectrum In Vivo Imaging System and Living Image software
    • Advanced necropsy and tissue collection
  • Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays (includes 2 floating holidays)


Why join Moderna

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

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Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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