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POSTDOCTORAL FELLOW at FDA

Employer
Center for Biologics Evaluation and Research (CBER) Food and Drug Administration (FDA)
Location
Silver Spring, Maryland, USA
Salary
A competitive salary will be offered depending on candidate's experience, up to $74,999 per annum
Closing date
Dec 31, 2019

The Laboratory of Retrovirus Research at the Center for Biologics Evaluation and Research (CBER) Food and Drug Administration (FDA) located in Silver Spring, MD, USA is seeking postdoctoral fellow to study safety and Mode of Action of Adjuvants in human cells and animal models.

Adjuvants are added to vaccine formulations to augment immune responses to the vaccine antigens by enhancing antigen processing and presentation by antigen presenting cells (APC). In some cases, activation of APC by adjuvants may cause a release of pro-inflammatory cytokines and prostaglandin E2 (PGE2) leading to undesired inflammatory responses in vaccine recipients. Recently, we demonstrated that production of pro-inflammatory mediators by monocytes in response to MDP adjuvant requires cooperation between signaling from cytosolic NOD2 (signal 1) and Mac-1 integrin (signal 2) (Liu, F. et al., Science Signaling DOI: 10.1126/scisignal.aat6023). The candidate is expected to characterize the molecular mechanisms by which adjuvants engage innate immunity including signaling pathways and epigenetic changes leading to production of pro-inflammatory mediators including PGE2. Preference will be given to candidates with strong expertise in molecular biology. Experience in confocal microscopy and in transcription factor binding assays will be helpful. This is a non-tenure track position.

Interested candidates should have a Ph.D. degree with no more than 4 years of relevant post-doctoral training. U.S. citizens and U.S. permanent residents who lived in the US for at least 3 out of 5 years should apply. To apply, please submit a cover letter, curriculum vitae, and the names and e-mail addresses of at least three references to Dr. Hana Golding Hana.Golding@fda.hhs.gov and Dr. Marina Zaitseva Marina.Zaitseva@fda.hhs.gov.

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