Postdoctoral Fellow - Computational Biology

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Williams lab is looking for a Postdoctoral Fellow to work with a dedicated team of structural, molecular, cellular and cancer biologists to develop next generation of protein biologics. Dedicated GPU cluster, access to multiple software packages, and additional resources are in place to ensure success. Rapid evaluation and translation of computationally-derived molecules (pipeline built to produce up to 100 mAbs per week and evaluated using biophysical methods {SPR, ITC, DSF, X-ray diffraction} and multiple cell based assays).

The Beckman Research Institute is home to more than 120 Principal Investigators, over 27 core facilities including three FDA approved GMP facilities, and seemless integration with clinicians. Some of the most important break-throughs in modern medicine have roots at City of Hope, including recombinant insulin (Humalin) and humanization of monoclonal antibodies (leading to Rituxan, Herceptin, and others).

Basic education, experience and skills required for consideration:

• PhD in chemistry, protein engineering, physics or related field
• Must have peer-reviewed publications demonstrating competence in computational methods including de novo modeling and molecular dynamics. Designs will be characterized experimental, using such information as part of an iterative process to rapidly product novel therapeutics.
• Must have excellent communication and organizational skills and is expected to work as part of a team

Preferred education, experience and skills:

• Previous experience with Rosetta, Schroedinger Suite and other MD methods
• Coding experience for novel algorithms, interfacing with standard software
• Experience with MATLAB

Additional Information:

• For more information about Dr. Williams' research, please click here .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.