Computational Genomic Scientist, Dept of Pharmacology, Weill Cornell Medicine

Computational Genomic Scientist

Department of Pharmacology

Weill Cornell Medical College of Cornell University

Our laboratory is interested in the impact of adverse and beneficial environmental conditions, such as stress and exercise, on the neuronal epigenome in individuals and their progeny in animal models. 

As a Computational Genomic Scientist in the Toth lab you will:

• Be responsible for designing and carrying out bioinformatics and biostatistical analyses of next generation sequencing (NGS) datasets produced in our Epigenomic and Genomic Core Facilities.

• Collaborate with other researchers in the lab, advising them on experimental design, data handling and analysis practices for a variety of experimental approaches, including whole genome sequencing, RNA-seq, 10X single cell gene expression, RRBS, single-nucleus RRBS, and other epigenomic methods.

• Have access to some of the best research facilities in the world as well as the opportunity to improve your current skills through educational access to a wide range of workshops, seminars, classes and one-on-one training sessions.

The successful applicant for this position will be expected to produce automated pipelines and/or use already established pipelines for large scale data analyses in support of basic science research, tracking all phases of the NGS data lifecycle, from initial processing of raw data acquired from from instruments, through primary and secondary analyses, and to data visualization, secure data dissemination, and long-term archiving. Additionally, you will be familiar with best practices and the current literature in the field, and fluent with commonly used tools (e.g. R) as well as databases.

The Toth laboratory explores diverse topics in neuroscience and psychiatry spanning genetics, epigenetics, gene expression, neuronal development, morphology and function and cognitive and emotional behavior.  Therefore, the laboratory environment provides an opportunity to work in broad and interdisciplinary areas of research. The laboratory environment is highly collegial and interactive.

Some relevant publication from our laboratory:

-- Oh J.E., et al. Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment. Translational Psychiatry, Nature Pub. Group. 2013; 3: e218. 22 January 2013.

--.Toth M. Mechanisms of Non-Genetic Inheritance and Psychiatric Disorders. Review. Neuropsychopharmacology. 2014 Jun 3. doi: 10.1038/npp.2014.127.

-- Sharma A, Klein SS, Barboza L, Lohdi N, Toth M. Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification. The Journal of neuroscience 36(5):1711-22, 2016. PMID: 26843651 PMCID: PMC4737779

-- Mitchell E, Klein S, Argyropoulos VK, Sharma S, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, Brink M, Toth M. Behavioral traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature Communications 7:11492. DOI: 10.1038/ncomms11492, 2016.

Requirements:

Education

• Bachelor’s Degree in related field

Experience

B.S. in molecular biology, genetics, bioinformatics, or computer science is desired.

MS or PhD in systems biology, bioinformatics or computer biology is highly desired.

Approximately 3 years of related experience.

Bioinformatics analysis expertise as demonstrated by published papers.

Experience in biology is preferred.

Experience working in an academic environment is highly desired.

Previous experience in designing and building bioinformatics workflows preferred.

Previous experience analyzing and summarizing genomic datasets preferred.

Knowledge, Skills and Abilities

• Excellent communication skills.

• Understanding of biology and biomedicine.

• Ability to work with limited supervision.

Weill Cornell Medical College is located in Manhattan, New York, immediately adjacent to the Sloan Kettering Institute and Rockefeller University. This "tri-institutional campus" includes several hundred principal investigators, and has one of the highest densities of biomedical scientists in the world. This rich scientific environment provides unique and unparalleled research training opportunities, including seminars given by scientific leaders from throughout the world, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities. Questions and/or applications, comprising a CV, statement of research interests, and the date that you can start, should be e-mailed to Dr. Miklos Toth at mtoth@med.cornell.edu

Weill Cornell Medical College is an equal opportunity, affirmative action educator and employer.