Research Specialist - CRISPR/Cas9 - Newmark Lab
Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time. HHMI scientists have radically advanced the understanding of cells, the brain, the immune system, the development of organs, and how to treat many diseases. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S.
We currently have an opening for a Research Specialist focused on CRISPR/Cas9 work in the lab of Dr. Phillip Newmark at the University of Wisconsin-Madison and the Morgridge Institute for Research. Dr. Newmark’s lab seeks to understand how some animals can regenerate missing tissues. Specifically, they study planarians, a kind of flatworm that can regenerate an entire body from fragmented parts – a process which relies on stem cells. They investigate how stem cells are regulated to produce missing tissues. Insights from their work on fundamental planarian biology led them to study schistosomes and tapeworms (types of parasitic flatworms), which rely on similar stem cells for their propagation. Learning how parasitic flatworms infect their hosts and reproduce inside them could lead to new strategies for controlling these devastating parasites infecting hundreds of millions of people.
To learn more about the work of the lab, please visit their website: http://morgridge.org/research/regenerative-biology/newmark-lab/ or their Twitter: @planapalooza
To be considered for this role, please apply on the HHMI Careers site - do not reach out to the lab directly. Also, please include a cover letter with your application.
Representative Essential Duties and Responsibilities:
- Lead development of transgenic technologies for planarian
- Generate gene knock-outs and knock-in reporter lines.
- Independently design and conduct experiments under the supervision of Principal Investigator.
- Conduct literature reviews to be used in determining most suitable research methods.
- May configure, operate, and/or maintain specialized
- Identify methodological problems in research protocol and implement modifications to optimize experimental results.
- May use software applications to assemble, manipulate, format and/or perform statistical analyses of
- Prepare and present written or oral progress reports concerning studies.
- Present data to the Principal Investigator (monthly progress reports), to the entire lab (lab meetings ~1-2 times a year), and occasionally at scientific
- Train others in complex technical protocols.
Organizational Scope and Impact of Position
- Shares significant responsibility for results of research project or project team. Manages own research project with input of the Investigator. Intermediate to long term impact on results of entire lab.
- Successful candidate has the chance to work in the exciting and rapidly expanding field of planarian regeneration with a diverse group of talented and dedicated scientists.
- Play a vital collaborative role in the Newmark lab and actively contribute to research efforts of other lab members.
Required Education and Experience
- PhD. (currently or by May 2020) with experience in biochemistry and molecular biology
- Expertise in generating transgenic lines, preferably at the organismal level
- Knowledge of or experience with current CRISPR/Cas9 technologies
- Experience with viewing and analyzing genomic/transcriptomic sequence data
- Knowledge of or experience with current molecular cloning methodologies
- Excellent troubleshooting and organizational abilities
- Excellent oral communication and interpersonal skills
HHMI is an Equal Opportunity Employer.