Postdoctoral Fellow to study role of STAT3 in anti-tumor immunity
The Grandis/Johnson Head and Neck Cancer Lab in the UCSF Department of Otolaryngology – Head and Neck Surgery is dedicated to increasing our understanding of head and neck squamous cell carcinoma (HNSCC) and developing new treatment approaches.
We are seeking a motivated postdoctoral candidate with a background in molecular/cellular biology or immunology to lead investigation of the role of STAT3 transcription factor in anti-tumor immunity. The postdoctoral fellow will be co-mentored by Jennifer Grandis, MD, a physician scientist with expertise in HNSCC biology and clinical trial development, and Daniel Johnson, PhD, with expertise in cellular signaling and drug development. We emphasize a collaborative, team-science approach, and the fellow will be expected to interact well with statisticians, bioinformaticians, clinician scientists, and other lab members.
The fellow will use cutting-edge techniques and novel agents to target STAT3 and determine effects on HNSCC oncogenic properties and tumor growth, as well as host anti-tumor immunity. Studies will incorporate cell lines, organoids, patient-derived xenografts, and immunocompetent tumor models. Immune experiments will utilize multi-parameter flow cytometry and mass cytometry (CyTOF).
The position is funded by a newly awarded NIH R01 grant. The fellow will also be expected to apply for postdoctoral grants. Required background and skills:
- PhD in molecular/cellular biology or immunology
- Experience with cellular and animal models of cancer
- Desire to work in a collaborative enviroment
- Excellent organizational and communication skills
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