Postdoctoral Fellow to study role of STAT3 in anti-tumor immunity

Employer
University of California San Francisco
Location
University of California San Francisco
Salary
Commensurate with NIH guidelines
Posted
October 18 2019
Ref
48791
Position Type
Full Time
Organization Type
Academia

The Grandis/Johnson Head and Neck Cancer Lab in the UCSF Department of Otolaryngology – Head and Neck Surgery is dedicated to increasing our understanding of head and neck squamous cell carcinoma (HNSCC) and developing new treatment approaches. 

We are seeking a motivated postdoctoral candidate with a background in molecular/cellular biology or immunology to lead investigation of the role of STAT3 transcription factor in anti-tumor immunity.  The postdoctoral fellow will be co-mentored by Jennifer Grandis, MD, a physician scientist with expertise in HNSCC biology and clinical trial development, and Daniel Johnson, PhD, with expertise in cellular signaling and drug development.  We emphasize a collaborative, team-science approach, and the fellow will be expected to interact well with statisticians, bioinformaticians, clinician scientists, and other lab members.

The fellow will use cutting-edge techniques and novel agents to target STAT3 and determine effects on HNSCC oncogenic properties and tumor growth, as well as host anti-tumor immunity.  Studies will incorporate cell lines, organoids, patient-derived xenografts, and immunocompetent tumor models.  Immune experiments will utilize multi-parameter flow cytometry and mass cytometry (CyTOF). 

The position is funded by a newly awarded NIH R01 grant.  The fellow will also be expected to apply for postdoctoral grants.  Required background and skills:

  • PhD in molecular/cellular biology or immunology
  • Experience with cellular and animal models of cancer
  • Desire to work in a collaborative enviroment
  • Excellent organizational and communication skills

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