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Research Investigator

Employer
University of Texas MD Anderson Cancer Center
Location
Houston, Texas
Salary
Competitive
Closing date
Oct 21, 2019

View more

Discipline
Life Sciences, Cancer Research
Organization Type
Healthcare/Hospital

Job Details

Research Investigator

Job Responsibilities

Research and Design Activities.
Assists principal investigator with scientific research projects. Functions in a separate and independent manner in the design and initiation of research experiments. Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. Represents department or research committees as needed. Plans, organizes, coordinates and participates in scientific research projects. Participates in research activities developing new and innovative techniques working with large numbers of materials and data, developing and implementing support systems to document research results. Applies technical expertise and experience to plan, coordinate, design, supervise, and carry out research projects. Molecular cloning: genomic, cDNA, and mutation library construction; protein expression and purification; Northern, Southern and Western blotting; chromatin and protein immunoprecipitation; yeast and mammalian two-hybrid analysis; semi-quantitative reverse transcriptase-PCR and real-time PCR; in vitro kinase activity assays. In vivo studies: animal experimentation, including making constructs for knockout, conditional knockout and drug-inducible and tissue specific transgenic mice, mouse ES cell culturing, positive clone screening and identification, mouse genotyping, nude mouse tumor modeling, including subcutaneous, intraperitoneal, and intravenous tumor and agent introduction, mouse handling and surgery using ACUF-approved protocols, and rabbit and rat handling. Cell culture techniques: preparation of primary cultures from tissues, establishment of stable cell lines using retroviral or lentiviral transduction, plasmid transfection, knockdown, Tet-on and off systems, cDNA expression, microRNA, shRNA, and antagomir expression, drug IC50 titration and determination of synergy using combination index analysis, cell transfection, trans-well cell invasive and migration assays, clonogenicity assay, anoikis and autophagy assays, dual luciferase assays, and wound healing assays. Immunological methods: monoclonal antibody preparation and genetic engineering of antibodies, immunofluorescence and immunohistochemistry, including tissue preparation, sectioning and immunostaining; immunofluorescence and confocal microscopy, as well as electron microscopy techniques, and ELISAs.

Lab Operations.
Designs, develops or adapts equipment used in experiments or research to obtain desired results. Uses laboratory knowledge and expertise to identify and resolve laboratory operational issues and interacts with all levels of internal and external sources to resolve problems. Ensures laboratory adherence to safety standards. Supervise, coordinate, implement, and evaluate the various activities, functions, and procedures involving the daily activity within the research lab. Requires knowledge of the utilization of the majority of laboratory equipment and its maintenance.

Training and Publications.
Responsible for training junior staff to work in selected technical areas, as well as training in all areas of safety. Compiles, writes and evaluates data for publication purposes and submits project results to PI in appropriate digital format. It is necessary for the Research Investigator to perform peer reviews of published scientific articles to validate theories and corroborate research. Actively prepares and submits for presentation and peer-reviewed publication abstracts and manuscripts related to research outcomes. The investigator will be expected to be able to present the results of their work in laboratory research meetings. Subject to the ability and inclination of the individual, as well as the judgment of the principal investigator, opportunities to present findings at national meetings may arise as well. This individual will share in authorship of all publications which arise from this work in a manner to be determined by the principal investigator, and in proportion to their role in the research findings.
Education Required: Bachelor's degree in one of the natural sciences or related field.

Experience Required: Five years of experience in scientific or experimental research work. With preferred degree, three years of required experience.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Company

The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report's 2023 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute.

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