Post-Doctoral Scientists– Rush Alzheimer’s Disease Center

Employer
Rush University Medical Center
Location
Chicago, Illinois
Salary
Competitive
Posted
October 16 2019
Position Type
Full Time
Organization Type
Healthcare/Hospital
Job Type
Postdoc

Post-Doctoral Scientists– Rush Alzheimer’s Disease Center

At Rush University Medical Center in Chicago, Illinois, you won't just find a career – you'll discover an exclusive experience that gives you an opportunity to learn more, grow more and become more. Our staff demonstrates an unwavering commitment to patient care, consistently performing at a level that is extraordinary. As part of our team, you’ll discover why our unique combination of research and patient care has earned us national ranking by U.S. News & World Report, as well as an ANCC Magnet™ designation for the fourth consecutive time. What’s more, you’ll work in Chicago, one of the most popular cultural, historical and diverse cities in the nation.

Over the past decades, the Rush Alzheimer’s Disease Center (RADC) has carried out numerous community-based clinical-pathologic cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/).  The Human Cell Modeling Group at RADC is using induced pluripotent stem cells (iPSCs), direct lineage conversion and CRISPR/Cas9-based genetic approaches to investigate disease molecular mechanisms and discover genetic drivers of Alzheimer's disease. To expand this ongoing effort, we are seeking two highly motivated Post-Doctoral Scientists in Human Stem Cell Modeling and Genome Engineering.

Responsibilities

  • Develop novel multicellular 2D and 3D brain models using human iPSCs
  • Conduct CRISPR/Cas9-based genetic screening and genome engineering to identify potential disease driver genes
  • Develop molecular, cellular and functional assays to measure AD disease phenotypes
  • Develop High-Throughput Screening and High-Content Analysis platforms for genetic/compound screening

Requirements

  • PhD or MD or equivalent degree in the fields of stem cell biology, developmental neurobiology, neuroscience, molecular biology, functional genomics or related fields
  • Excellent skills and experience in human iPSC derivation, stem cell culture, neural differentiation and direct neural lineage conversion
  • Excellent skills and experience in CRISPR/Cas9-based genetic screening and cell line engineering
  • Extensive demonstrated experience in molecular biology and genetics/genomics including DNA/RNA isolation and manipulation, vector cloning, PCR and qPCR
  • Experience with high-throughput screening and next generation sequencing is a plus

To apply, please submit your resume to: Yanling_Wang@rush.edu

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status and other legally protected characteristics

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