Postdoctoral Fellow - Solid Tumor Animal Model

Duarte, California
October 15 2019
Life Sciences
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A Postdoctoral Fellow position is available immediately in the laboratory of Dr. David Ann, Ph.D. at Beckman Research Institute of City of Hope.

About the Ann Laboratory

Funded by NIH continually, Dr. Ann's lab is interested in the role of post-translational modifications, such as autophagy, phosphorylation, acetylation, SUMOylation, O-GlcNAcylation and ubiquitination in human metabolic disorders, including cancers and diabetes/obesity, with a particular focus on diet-induced metabolic reprogramming and rewiring. Ann lab's work aims to develop the pathogenic link among diet, aberrant metabolism and cancer progression. These studies will provide mechanistic insights that lead to not only effective dietary advice to lower cancer risk, but also development of novel diet-targeting therapies for cancer treatment and prevention.

Key Responsibilities include:
  • Under the direction of the Principal Investigator, develops and executes research projects by making significant, original contributions to hypothesis-driven research method development, data interpretation, result presentation; including authorship or co-authorship of published findings.
  • Carries out all laboratory activities in compliance with the approved IBC protocol by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.
  • Skillful in mouse survival surgery, tissue recovery and maintenance of mouse colonies in accordance with the approved IACUC protocol.
  • Proficient in cell and molecular biological techniques, including cell metabolism research, primary cell culture, flow cytometry, IHC, RNAseq and real-time PCR.
  • Keeps abreast of new and improved methodologies and technologies.
  • Participate in the preparation of research grants, manuscripts and presentations.
  • The candidate must follow established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality.
  • Performs other research-related duties as assigned or requested by PI.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in biomedical sciences, tumor biology or a related discipline is required.
  • Ability to effectively communicate with other lab members in order to successfully meet deadlines and perform and prioritize simultaneous tasks.
  • Ability to design and execute experiments, critically interpret experimental results, and present data effectively.
  • Sound technical skills and working ethics, and capable of drafting grant proposals and manuscripts.

Additional Information:
  • For more information on Dr. Ann's research, please visit:

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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