Postdoctoral Fellow position open in the laboratory of Matt Trudeau at the University of Maryland School of Medicine in Baltimore, MD.
We work to uncover the mechanisms of gating, regulation and disease in voltage-activated potassium channels, with a focus on hERG potassium channels. Our studies of inherited mutations in hERG potassium channels, which cause sudden death cardiac arrhythmias, are informed by biophysical knowledge of channel function. We also study the interactions of small molecules with hERG channels, as the off-site inhibition of hERG channels by drugs is a major clinical problem. Postdoctoral Fellows will have the opportunity to work on projects in several related areas. On-going projects involve combining fluorescence spectroscopy, electrophysiology and non-canonical amino acid (ncAA) technology to introduce ncAAs with novel sidechain ‘handles’ into hERG. We are focused on ncAAs that are fluorescent or photo-reactive. Using ncAA probes is anticipated to yield new insights into the molecular motions and protein dynamics that underlie gating of hERG. Postdocs will learn patch-clamp fluorometry (PCF) in which current and fluorescence measurements are acquired simultaneously from an excised, inside-out membrane patches and voltage-clamp fluorometry. Other related projects investigate the molecular and physiological interactions and regulation of two hERG channel isoforms, hERG1a and hERG1b that together form the native hERG current in the heart. Projects also focus on using CRISPR/Cas9 gene editing to study hERG currents in stem-cell derived cardiomyocytes. UMSOM also has formal career development opportunities for postdocs, including an Office of Postdoctoral Scholar (OPS) which features grant writing and other professional activities.
Postdoc position in the Trudeau Lab are supported by two R01 grants from NIH/NIGMS. Interested candidates should submit a cover letter and CV along with the names of three references to email@example.com. Individuals from underrepresented groups in the sciences are especially encouraged to apply.
More information about the lab can be found here: http://www.medschool.umaryland.edu/profiles/Trudeau-Matthew/
About University of Maryland School of Medicine
The University of Maryland School of Medicine is located in Baltimore adjacent to Oriole Park at Camden Yards and the Raven’s M&T Bank Stadium and within easy walking distance of the excellent dining, shopping, and entertainment at Baltimore's Inner Harbor. The West Side Cultural District surrounds the University and includes a variety of new residential, retail, and performing arts venues. Neighboring areas of Mt Vernon, Federal Hill, Fells Point, Canton, and Harbor East are vibrant, rapidly growing residential areas. Nationally ranked schools from kindergarten through high school are found in Baltimore's many private academies and the surrounding county public school systems. The Department is roughly 60 minutes from NIH and and just 38 miles from the National Mall in Washington, DC.
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