Washington University School of Medicine
Saint Louis, Missouri (US)
August 29 2019
Organization Type
Job Type

There is an opportunity for post-doctoral research in the laboratory of Dr. Grant Challen (Washington University, St. Louis, USA), which studies how genetic mutations influence the function of blood-forming stem cells in the bone marrow (hematopoietic stem cells = ‘”HSCs”) and contribute to the development of blood cancers. The Challen lab using cutting-edge techniques such as next-generation sequencing, CRISPR/Cas9 and high-throughput flow cytometry in model systems incorporating cancer cell lines, transgenic mouse models, and primary cells from human patients.

The successful candidate will have the opportunity to work on any number of projects investigating how epigenetic modifications influence HSC fate decisions, and how genetic mutations in epigenetic regulators contribute to clonal expansion of mutant HSCs in clonal hematopoiesis and predispose for transformation to hematopoietic malignancies. The post-doctoral scholar will be responsible for managing their own projects (under the mentorship of Dr. Challen) as well as contributing to ongoing projects with other trainees. Must have troubleshooting skills, independent analytical thinking and research planning skills as well as demonstrated ability to work independently and communicate with the laboratory staff and investigators. Experience in flow cytometry and small animal handling is desirable. For more information about our lab research please visit our website ( and follow us on Twitter (@challenlab). Qualified candidates can contact Dr. Grant Challen ( with CV and research statement attached.

Washington University is an Equal Opportunity Employer.