PhD student position (m/f/d) in protein homeostasis and haematopoiesis

The Max Planck Institute of Biochemistry is one of the leading research institutes within the fields of biochemistry, cell- and structural biology and biomedicine. With its eight scientific departments, about 25 research groups, and a staff of around 850 people, the institute is one of the largest institutes within the Max Planck Society. We offer a

PhD student position (m/f/d) in protein homeostasis and haematopoiesis

The laboratory of Dr. Alpi in the Department of Molecular Machines and Signaling is dedicated to unravel the in vivo cellular and molecular mechanisms that regulate protein homeostasis in haematopoiesis by focusing on the autophagy and ubiquitin-proteasome systems. We recently employed genetic screens and mass spectrometry-based proteomics to identify novel key players in the ubiquitin system required for haematopoiesis. The PhD project will focus on further characterising these candidates using cutting-edge biological approaches, including stem/progenitor cell model systems, genetic engineering (CRISPR-Cas9), flow cytometry, high-resolution microscopy, and deep sequencing technologies (RNA-Seq, ChIP-Seq).

The successful candidate will have a master degree in cell biology and a keen interest in cell differentiation. Previous expertise in mammalian cell culture and techniques such microscopy and flow cytometry are highly desired. Additional experience in working with stem/progenitor cells and training with mass spectrometry analysis is considered a merit.

The successful applicant will receive an appointment with a competitive salary (TVöD E13, 70% - public tariff scale) and benefit from opportunities for additional training and attendance of international conferences. The position is fully funded for three years (extendable to four).

The Max-Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the
Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

Informal enquiries can be directed to Dr. Arno Alpi (aalpi@biochem.mpg.de).

If you are interested, please submit your appropriate documents (including a cover letter stating your research interest in haematopoiesis, your CV and contact details of two academic referees) online as pdf files by the 18^th of October 2019. Please click here.