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Postdoctoral Position in kidney injury/fibrosis and kidney-heart or kidney-lung interorgan crosstalk

Employer
Washington University in St.Louis
Location
Washington University School of Medicine in St. Louis, MO, USA
Salary
Salary will be paid according to NIH scale + benefits
Closing date
Oct 7, 2019
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The Herrlich Lab investigates cellular and molecular mechanisms of tissue injury, repair and fibrosis in the kidney and their deleterious consequences for other organs (interorgan-crosstalk/communication), such as between kidney, heart, and lung. www.herrlichlab.org

Acute kidney injury (AKI) and fibrotic chronic kidney disease (CKD) and their secondary complications, in particular in the heart (myocardial infarction, cardiovascular disease) and lung (acute lung injury, ALI), are highly prevalent world-wide and cause significant morbidity and mortality. Therapeutic strategies to prevent acute kidney injury/fibrosis and secondary organ damage are lacking.

Recently, we are particularly interested in kidney-released growth factors, cytokines and their receptors that control injury, repair and fibrosis in the kidney and are involved in interorgan crosstalk.

We are using mouse models  of AKI and CKD, combined with cardiac or lung injury, as well as cell culture models. We are defining critical cell types and signaling mediators/pathways using a combination of cell-based studies, genomic/computational analysis (shRNA, siRNA, CRISPR-Cas9, functional genomics, single cell RNAseq), novel genetically-engineered mouse models, clinical specimens, and targeted therapeutics.

The ideal candidate will have a strong background in molecular/cellular biology and biochemistry and experience with the handling of mice. The position is immediately available. To apply please submit a letter describing your interests, CV and contact info for three references to Andreas Herrlich MD PhD: aherrlich@gmail.com.

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